Thomas R. Shelite

TL;DR: It seems that chigger cofeeding on rodents is more relevant for effective mouseto-mite transmission of Orientia than feeding on rickettsemic hosts, and the true role of rodents as reservoirs requires additional investigation, because there may be marked genetic variability in chiggers with respect to the ability to acquire rickettsiae by feeding.

TL;DR: It is shown that a small-molecule Epac inhibitor can prevent and suppress rickettsial infection, and deletion of the exchange protein directly activated by cAMP (Epac) gene, Epac1, in mice protects them from an ordinarily lethal dose of ricksettsiae.

TL;DR: The ways in which neutrophils have been observed to prevent and promote the establishment of infection are discussed, the role of anti‐neutrophil antibodies in mouse models of leishmaniasis is examined and recent findings that neutrophil may play a previously unrecognized role in influencing chronic parasite persistence are considered.

TL;DR: The first report of selective alterations in a panel of immune regulators during early O. tsutsugamushi infection in intravenously inoculated C57BL/6 mice is reported, shedding new light on the pathogenic mechanisms associated with severe scrub typhus and suggest potential targets for therapeutic investigation.

TL;DR: In this article, an intriguing hypothesis about a novel cytoplasmic role of angiogenin was raised, which is induced upon infection with spotted fever group (SFG) rickettsia and generates tRNA-derived RNA fragments (tRFs) that may play roles in SFG rICKettsioses.