Thomas Su

TL;DR: A strategy to rapidly and efficiently isolate ribosome-associated mRNA transcripts from any cell type in vivo is described and the application of this technique is demonstrated in brain using neuron-specific Cre recombinase-expressing mice and in testis using a Sertoli cell Cre recomb inase- expressing mouse.

TL;DR: Analysis of sperm in Calpha knockout males revealed that spermatogenesis progressed normally but that mature sperm had defective forward motility, and growth retardation was not due to decreased GH production but did correlate with a reduction in IGF-I mRNA in the liver and diminished production of the major urinary proteins in kidney.

TL;DR: Evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains.

TL;DR: It is demonstrated that unregulated PKA activity negatively affects growth factor-mediated mesoderm formation during early mouse development and can be completely rescued by crossing RIα mutants to mice carrying a targeted disruption in the Cα catalytic subunit.

TL;DR: The results indicate that the targeting of calcineurin or other binding partners of AKAP5 in the absence of the balancing kinase, PKA, leads to a disruption of synaptic plasticity and results in learning and memory defects.