Thomas Taupitz

TL;DR: The newly developed physiologically based pharmacokinetic (PBPK) in silico model predicted that the bioavailability of itraconazole is likely to be increased after oral administration of ternary complex formulations, especially when it raconazoles is formulated as a ternARY complex comprising HP-β-CD or HBen-β -CD and Soluplus®.

TL;DR: The bioavailability of both drugs in the fixed doses combination is likely to be increased after oral administration of the new formulations, especially when the fixed dose combination is formulated as a ternary complex consisting of HP-β-CD and Soluplus.

TL;DR: Overall, the miniaturized transfer model appeared to be the best single tool for rank-ordering formulations of the poorly soluble, weakly basic model compound ketoconazole (KETO) after oral administration.

TL;DR: Results from this study indicate that the concentration of surfactant has a huge impact on both the rate and extent of drug release from the formulation and also on the discriminatory power of the test, and indicate that a well designed and validated test medium containing SLS or Tween 80 can be useful in terms of establishing a discriminatory test medium.

TL;DR: In this paper, the authors developed predictive and discriminatory test methods based on surfactants that are recommended in the literature for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of for-mulations.