S
Sandra Klein
Researcher at University of Greifswald
Publications - 89
Citations - 2886
Sandra Klein is an academic researcher from University of Greifswald. The author has contributed to research in topics: Dissolution testing & Dosage form. The author has an hindex of 26, co-authored 79 publications receiving 2329 citations. Previous affiliations of Sandra Klein include Goethe University Frankfurt.
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Journal ArticleDOI
The Use of Biorelevant Dissolution Media to Forecast the in Vivo Performance of a Drug
TL;DR: An overview of the development and composition of biorelevant dissolution media that can be used for the in vitro simulation of different dosing conditions (fasted and fed states) and the application of these media to predicting food effects is described.
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In vitro models for the prediction of in vivo performance of oral dosage forms
Edmund Kostewicz,Bertil Abrahamsson,Marcus E. Brewster,Joachim Brouwers,James Butler,Sara Carlert,Paul A. Dickinson,Jennifer B. Dressman,René Holm,Sandra Klein,James Mann,Mark McAllister,Mans Minekus,Uwe Muenster,Anette Müllertz,Miriam Verwei,Maria Vertzoni,Werner Weitschies,Patrick Augustijns +18 more
TL;DR: It is anticipated that the innovative in vitro biopharmaceutical tools arising from the OrBiTo project will lead to improved predictions for in vivo behavior of drug formulations in the GI tract.
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A new 5-aminosalicylic acid multi-unit dosage form for the therapy of ulcerative colitis.
TL;DR: The aim of the present study was to develop a multi-unit dosage form containing 5-aminosalicylic acid (5-ASA) for the treatment of ulcerative colitis, optimised on the basis of recent studies indicating that UC patients have higher intestinal pH than was previously thought to be the case.
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Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
Cordula Stillhart,Katarina Vučićević,Patrick Augustijns,Abdul Basit,Hannah Batchelor,Talia Flanagan,Ina Gesquiere,Rick Greupink,Daniel Keszthelyi,Mikko Koskinen,Christine M. Madla,Christophe Matthys,Goran Miljuš,Miriam G. Mooij,Miriam G. Mooij,Neil Parrott,Anna Lena Ungell,Saskia N. de Wildt,Saskia N. de Wildt,Mine Orlu,Sandra Klein,Anette Müllertz +21 more
TL;DR: This review provides an overview of GI tract properties in special populations compared to healthy adults and discusses how drug absorption is affected by these conditions.
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Media to simulate the postprandial stomach I. Matching the physicochemical characteristics of standard breakfasts
TL;DR: To better predict food effects on the bioavailability/bioequivalence of drugs and drug products from in‐vitro data, a dissolution medium that simulates the initial composition of the postprandial stomach was developed.