Thomas Vogel

TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.

TL;DR: Normothermic machine perfusion might transpire to be the ideal vehicle to deliver other therapeutic interventions during preservation to modulate and optimize the graft before transplantation by restoring function in marginal donor organs and enabling the clinician to appraise its viability, the donor pool might be greatly expanded.

TL;DR: Normothermic perfusion preservation of human livers for 24 hours was shown to be technically feasible and positive correlation between instantly available perfusion parameters and generally accepted predictors of posttransplant graft survival was found.

TL;DR: Avoidance of cold ischaemic preservation damage and repair of injury sustained during warm ischaemia and organ procurement would potentially allow many livers from extended criteria donors to be transplanted reliably.

TL;DR: A balanced overview on how machine preservation technologies, the coagulation system, antioxidants, cytoprotective agents, cytokines, preservation solutions, and the innate and adaptive immune system can be targeted to prevent IRI in liver transplantation is presented.