H
Hynek Mergental
Researcher at University of Birmingham
Publications - 103
Citations - 4155
Hynek Mergental is an academic researcher from University of Birmingham. The author has contributed to research in topics: Liver transplantation & Machine perfusion. The author has an hindex of 29, co-authored 95 publications receiving 2935 citations. Previous affiliations of Hynek Mergental include Churchill Hospital & National Institute for Health Research.
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Journal ArticleDOI
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more
TL;DR: Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Hynek Mergental,Hynek Mergental,M. T. P. R. Perera,Richard W. Laing,Paolo Muiesan,John Isaac,Amanda Smith,Barney Stephenson,Hentie Cilliers,Desley Neil,Stefan G. Hubscher,Simon C. Afford,Darius F. Mirza +12 more
TL;DR: Viability assessment of high‐risk grafts using NMP‐L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction, which may increase organ availability for LT.
Journal ArticleDOI
Transplantation of discarded livers following viability testing with normothermic machine perfusion
Hynek Mergental,Hynek Mergental,Richard W. Laing,Richard W. Laing,Amanda Kirkham,M. Thamara P. R. Perera,Yuri L. Boteon,Yuri L. Boteon,Joseph Attard,Joseph Attard,Darren Barton,Stuart M. Curbishley,Stuart M. Curbishley,Manpreet Wilkhu,Desley Neil,Desley Neil,Stefan G. Hübscher,Stefan G. Hübscher,Paolo Muiesan,John Isaac,Keith J. Roberts,Keith J. Roberts,Manuel Abradelo,A. Schlegel,A. Schlegel,James Ferguson,Hentie Cilliers,Julian Bion,David H. Adams,David H. Adams,Christopher Morris,P Friend,Christina Yap,Christina Yap,Simon C. Afford,Simon C. Afford,Darius F. Mirza,Darius F. Mirza +37 more
TL;DR: The VITTAL clinical trial as discussed by the authors used normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria, which enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent nonanastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.
Journal ArticleDOI
The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation.
Andrea Schlegel,Marit Kalisvaart,Irene Scalera,Richard W. Laing,Hynek Mergental,Darius F. Mirza,Thamara Perera,John Isaac,Philipp Dutkowski,Paolo Muiesan +9 more
TL;DR: The UK DCD Risk Score is a reliable tool to detect high-risk and futile combinations of donor-and-recipient factors in DCD liver transplantation and offers a great potential for making better decisions on which DCD graft should be rejected or may benefit from functional assessment and further optimization by machine perfusion.