Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TLDR
This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.About:
This article is published in American Journal of Transplantation.The article was published on 2016-03-07. It has received 373 citations till now. The article focuses on the topics: Transplantation & Machine perfusion.read more
Citations
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Journal ArticleDOI
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more
TL;DR: Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.
Journal ArticleDOI
Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches
Gonzalo Sapisochin,Jordi Bruix +1 more
TL;DR: A comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment is provided.
Journal ArticleDOI
Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Hynek Mergental,Hynek Mergental,M. T. P. R. Perera,Richard W. Laing,Paolo Muiesan,John Isaac,Amanda Smith,Barney Stephenson,Hentie Cilliers,Desley Neil,Stefan G. Hubscher,Simon C. Afford,Darius F. Mirza +12 more
TL;DR: Viability assessment of high‐risk grafts using NMP‐L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction, which may increase organ availability for LT.
Journal ArticleDOI
Observations on the ex situ perfusion of livers for transplantation.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Caitlin Pley,Lucy V. Randle,Corinna Fear,Keziah Crick,Alexander Gimson,Michael Allison,Sara Upponi,Rebecca Brais,Ina Jochmans,Andrew J. Butler +11 more
TL;DR: Evaluation of bile pH may offer a valuable insight into bile duct integrity and risk of posttransplant ischemic cholangiopathy, as well as a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid‐base balance.
Journal ArticleDOI
Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation
Andrea Schlegel,Andrea Schlegel,Xavier Muller,Marit Kalisvaart,Beat Muellhaupt,M. Thamara P. R. Perera,John Isaac,Pierre-Alain Clavien,Paolo Muiesan,Philipp Dutkowski +9 more
TL;DR: 5-year graft survival in donation after cardiac death livers treated by conventional cold storage, or by 1-2 h of hypothermic oxygenated perfusion (HOPE) after cold storage suggests that a simple end-ischaemic perfusion approach is very effective and may open the field for safe utilisation of extended DCD liver grafts.
References
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Journal ArticleDOI
No surgical innovation without evaluation: the IDEAL recommendations.
Peter McCulloch,Douglas G. Altman,W Bruce Campbell,David R. Flum,Paul Glasziou,John C. Marshall,Jon Nicholl +6 more
TL;DR: Recommendations for the assessment of surgery based on a five-stage description of the surgical development process are proposed and the widespread use of prospective databases and registries are encouraged.
Journal ArticleDOI
Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
Cyril Moers,Jacqueline M. Smits,Mark-Hugo J. Maathuis,Juergen Treckmann,Frank Van Gelder,Bogdan P. Napieralski,Margitta van Kasterop-Kutz,Jaap J. Homan van der Heide,Jean-Paul Squifflet,Ernest van Heurn,Guenter R. Kirste,Axel Rahmel,Henri G. D. Leuvenink,Andreas Paul,Jacques Pirenne,Rutger J. Ploeg +15 more
TL;DR: Hypothermic machine perfusion was associated with a reduced risk of delayed graft function and improved graft survival in the first year after transplantation.
Journal ArticleDOI
Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
Marcelo Cypel,Jonathan C. Yeung,Mingyao Liu,Masaki Anraku,Fengshi Chen,W. Karolak,Masaaki Sato,Jane Laratta,Sassan Azad,Mindy Madonik,Chung-Wai Chow,Cecilia Chaparro,Michael Hutcheon,Lianne G. Singer,Arthur S. Slutsky,Kazuhiro Yasufuku,Marc de Perrot,Andrew Pierre,Thomas K. Waddell,Shaf Keshavjee +19 more
TL;DR: Transplantation of high-risk donor lungs that were physiologically stable during 4 hours of ex vivo perfusion led to results similar to those obtained with conventionally selected lungs.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Related Papers (5)
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more