Thomas W. Smith

TL;DR: It is found that membrane potentials across mitochondria in a living cell can be heterogeneous, and even within a long contiguous mitochondrion, regional heterogeneity in membranes potentials appears to be possible.

TL;DR: The authors compared three methods of collecting data about sexual behaviors and other sensitive topics: com- puter-assisted personal interviewing (CAPI), computer-assisted self-administered interviewing, and audio computer assisted self-directed interviewing (ACASI) with an area probability sample of more than 300 adults in Cook County, Illinois.

TL;DR: The spectral properties of a novel membrane potential sensitive probe (JC-1) were characterized in aqueous buffers and in isolated cardiac mitochondria and found to be pH independent within the physiological pH range of 7.15-8.0 and could be linearly calibrated with valinomycin-induced K+ diffusion potentials.

TL;DR: Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology.

TL;DR: Establishment of expression of eNOS in cardiac myocyte caveolae is established and tissue-specific and quantitative associations of e NOS with caveolin are document, which may have important implications for the regulation ofeNOS by caveolin isoforms and by other signaling proteins targeted to Caveolae.