Stephen T. Smiley

TL;DR: It is demonstrated that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses toIL-4 lymphocytes.

TL;DR: It is found that membrane potentials across mitochondria in a living cell can be heterogeneous, and even within a long contiguous mitochondrion, regional heterogeneity in membranes potentials appears to be possible.

TL;DR: It is suggested that innate responses to fibrinogen and bacterial endotoxin may converge at the evolutionarily conserved Toll-like recognition molecules, thereby promoting immune surveillance at sites of inflammation.

TL;DR: This chapter uses JC-1 to investigate the remaining questions about mitochondrial membrane potential in living cells, including the component of the electrochemical gradient that is responsible for the formation of J-aggregates, and the study of the variation of membrane potential within a given mitochondrion.

TL;DR: It is shown that acute cardiac allograft rejection is accompanied by progressive intragraft production of the chemokines interferon (IFN)-γ–inducible protein of 10 kD (IP-10), monokine induced by IFN-γ (Mig), andIFN-inducable T cell α chemoattractant (I-TAC), and by infiltration of activated T cells bearing the corresponding chemokine receptor, CXCR3.