T
Thorsten E. Fisher
Researcher at United States Military Academy
Publications - 28
Citations - 1459
Thorsten E. Fisher is an academic researcher from United States Military Academy. The author has contributed to research in topics: Integrase & Integrase inhibitor. The author has an hindex of 14, co-authored 28 publications receiving 1430 citations.
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Journal ArticleDOI
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Daria J. Hazuda,Neville J. Anthony,Robert P. Gomez,Samson M. Jolly,John S. Wai,Linghang Zhuang,Thorsten E. Fisher,Mark Embrey,James P. Guare,Melissa S. Egbertson,Joseph P. Vacca,Joel R. Huff,Peter J. Felock,Marc V. Witmer,Kara A. Stillmock,Robert M. Danovich,Jay A. Grobler,Michael D. Miller,Amy S. Espeseth,Lixia Jin,I.-W. Chen,Jiunn H. Lin,Kelem Kassahun,Joan D. Ellis,Bradley K. Wong,Wei Xu,Paul G. Pearson,William A. Schleif,Riccardo Cortese,Emilio A. Emini,Vincenzo Summa,M. Katharine Holloway,Steven D. Young +32 more
TL;DR: These studies provide a structural basis and rationale for developing integrase inhibitors with the potential for unique and nonoverlapping resistance profiles and propose a model of the two inhibitors that is consistent with this observation and suggests specific interactions with discrete binding sites for each ligand.
Journal ArticleDOI
Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells
Linghang Zhuang,John S. Wai,Mark Embrey,Thorsten E. Fisher,Melissa S. Egbertson,Payne Linda S,James P. Guare,Joseph P. Vacca,Daria J. Hazuda,Peter J. Felock,Abigail Wolfe,Kara A. Stillmock,Marc V. Witmer,Gregory Moyer,William A. Schleif,Lori J. Gabryelski,Yvonne M. Leonard,Joseph J. Lynch,Stuart R. Michelson,Steven D. Young +19 more
TL;DR: Naphthyridine 7 inhibits the strand transfer of the integration process catalyzed by integrase with an IC50 of 10 nM and inhibits 95% of the spread of HIV-1 infection in cell culture at 0.39 microM.
Journal ArticleDOI
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
John S. Wai,Melissa S. Egbertson,Payne Linda S,Thorsten E. Fisher,Mark Embrey,Tran Lekhanh O,Jeffrey Y. Melamed,H. Marie Langford,James P. Guare,Linghang Zhuang,Vanessa E. Grey,Joseph P. Vacca,M. Katharine Holloway,Adel M. Naylor-Olsen,Daria J. Hazuda,Peter J. Felock,Abigail Wolfe,Kara A. Stillmock,William A. Schleif,Lori J. Gabryelski,Steven D. Young +20 more
Journal ArticleDOI
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors
Walfred S. Saari,Jacob M. Hoffman,John S. Wai,Thorsten E. Fisher,Clarence S. Rooney,Anthony M. Smith,Thomas Cm,Mark E. Goldman,Julie A. O'Brien,J. H. Nunberg +9 more
Journal ArticleDOI
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one
W. S. Saari,John S. Wai,Thorsten E. Fisher,Thomas Cm,Jacob M. Hoffman,Clarence S. Rooney,Anthony M. Smith,James H. Jones,Dona L. Bamberger +8 more
TL;DR: A series of nonnucleoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties and several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM.