T
Ti-Chun Chao
Researcher at National Tsing Hua University
Publications - 4
Citations - 325
Ti-Chun Chao is an academic researcher from National Tsing Hua University. The author has contributed to research in topics: Viral replication & Replication factor C. The author has an hindex of 4, co-authored 4 publications receiving 307 citations. Previous affiliations of Ti-Chun Chao include Academia Sinica.
Papers
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Journal ArticleDOI
Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy
Wen-Chi Su,Ti-Chun Chao,Ti-Chun Chao,Yih-Leh Huang,Shih-Che Weng,King-Song Jeng,Michael M. C. Lai,Michael M. C. Lai +7 more
TL;DR: It is demonstrated that HCV nonstructural protein 4B (NS4B) alone can induce autophagy signaling; amino acid residues 1 to 190 of NS4B are sufficient for this induction.
Journal ArticleDOI
Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A
Yung-Chia Chen,Wen-Chi Su,Jing-Ying Huang,Ti-Chun Chao,Ti-Chun Chao,King-Song Jeng,Keigo Machida,Michael M. C. Lai +7 more
TL;DR: This study shows that Plk1 is an NS5A phosphokinase and thereby indirectly regulates HCV RNA replication and could potentially serve as a target for anti-HCV therapy.
Journal ArticleDOI
Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft
TL;DR: It is proposed that Anxa2 recruits HCV NS proteins and enriches them on the lipid raft to form the HCV replication complex.
Journal ArticleDOI
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), a Host Membrane-Deforming Protein, Is Critical for Membranous Web Formation in Hepatitis C Virus Replication
Ti-Chun Chao,Ti-Chun Chao,Wen-Chi Su,Jing-Ying Huang,Yung-Chia Chen,King-Song Jeng,Horng-Dar Wang,Michael M. C. Lai,Michael M. C. Lai,Michael M. C. Lai +9 more
TL;DR: It is suggested that PSTPIP2 facilitates membrane alterations and is a key player in the formation of the membranous web, which is the site of the HCV replication complex.