Tianfu Li

TL;DR: This work proposes the use of a flat–curved–flat imaging strategy, in which the sample plane is magnified onto a large spherical image surface and then seamlessly conjugated to multiple planar sensors, to perform video-rate, gigapixel imaging of biological dynamics at centimetre scale and micrometre resolution.

TL;DR: It is revealed that FS neurons in human association cortices could generate APs at a maximal mean frequency of 338 Hz and a maximal instantaneous frequency of 453 Hz, and they increase with age, while the maximal firing frequency of FS neurons varies between species and cortical areas.

TL;DR: It is shown that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection from other inputs, indicating that PC autapses are functional and represent an important circuit element in the neocortex.

TL;DR: The density and laminar distribution of different interneuron types and the co-expression of molecular markers in epileptic human cortex was investigated and it was found that parvalbumin and somatostatin neurons were distributed in all cortical layers except layer I, while tyrosine hydroxylase and neuropeptide Y were abundant in the deep layers and white matter.

TL;DR: Ifenprodil decreased neuronal excitability of neocortical pyramidal neurons in patients with epilepsy and MCD and demonstrated that ifen Prodil may be a potentially specific treatment for refractory epilepsy caused by MCD.