T
Tiangang Zhao
Researcher at Jilin University
Publications - 2
Citations - 38
Tiangang Zhao is an academic researcher from Jilin University. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 2, co-authored 2 publications receiving 30 citations.
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Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling
TL;DR: Combining therapy with CuB alone and in combination with SCH772984 resulted in highly significant growth inhibition of pancreatic cancer xenografts and may provide a basis for further development of combining CuB and ERK inhibitors to treat Pancreatic cancer.
Journal ArticleDOI
CHK1 inhibition sensitizes pancreatic cancer cells to gemcitabine via promoting CDK-dependent DNA damage and ribonucleotide reductase downregulation
TL;DR: Mechanistic investigations showed that gemcitabine sensitization by CHK1 inhibition was associated with CDK‑dependent RRM1/2 downregulation and DNA damage enhancement, which provides a basis for further development of combiningCHK1 inhibitors and gem citabine to treat pancreatic cancer.