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Tianyuan He

Researcher at University of Michigan

Publications -  26
Citations -  2159

Tianyuan He is an academic researcher from University of Michigan. The author has contributed to research in topics: Human skin & Extracellular matrix. The author has an hindex of 17, co-authored 21 publications receiving 1840 citations. Previous affiliations of Tianyuan He include Shanghai Jiao Tong University & University of Southern Mississippi.

Papers
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Journal ArticleDOI

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.

Gary J. Fisher, +8 more
- 01 Jan 2009 - 
TL;DR: It is proposed that this self perpetuating cycle of MMP-1-catalyzed collagen fragmentation and oxidative stress promotes human skin aging and the current understanding of the oxidative theory of aging is extended to include extracellular matrix and the critical role that connective tissue microenvironment plays in the biology of aging.
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Solar Ultraviolet Irradiation Reduces Collagen in Photoaged Human Skin by Blocking Transforming Growth Factor-β Type II Receptor/Smad Signaling

Taihao Quan, +4 more
- 01 Sep 2004 - 
TL;DR: It is reported here that UV irradiation impairs TGF-beta/Smad pathway in human skin by down-regulation of TbetaRII, with attendant reduction of type I procollagen production, a critical molecular mechanism in the pathophysiology of photoaging.
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Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin

Taihao Quan, +4 more
- 01 Feb 2010 - 
TL;DR: It is reported here that the TGF-beta/Smad/CTGF axis is significantly reduced in dermal fibroblasts, the major collagen-producing cells, in aged (> or = 80 years) human skin in vivo.
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Ultraviolet Irradiation Blocks Cellular Responses to Transforming Growth Factor-β by Down-regulating Its Type-II Receptor and Inducing Smad7 *

Taihao Quan, +3 more
- 13 Jul 2001 - 
TL;DR: It is reported that UV irradiation of mink lung epithelial cells causes near complete inhibition of TFG-β-induced Smad2/3-mediated gene expression, indicating thatUV irradiation blocks cellular responsiveness to TGF-β through two mechanisms that impair T GF-β receptor function.
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Ultraviolet irradiation alters transforming growth factor β/Smad pathway in human skin in vivo

Taihao Quan, +4 more
- 01 Aug 2002 - 
TL;DR: It is demonstrated that ultraviolet and solar-simulated ultraviolet irradiation alter the transforming growth factor beta/Smad pathway in human skin in vivo.