S
Sewon Kang
Researcher at University of Michigan
Publications - 163
Citations - 18622
Sewon Kang is an academic researcher from University of Michigan. The author has contributed to research in topics: Human skin & Photoaging. The author has an hindex of 63, co-authored 148 publications receiving 17386 citations. Previous affiliations of Sewon Kang include Johns Hopkins University & Pennsylvania State University.
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Journal ArticleDOI
Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
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Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
TL;DR: Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging.
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Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Gary J. Fisher,Subhash C. Datta,Harvinder S. Talwar,Zeng Quan Wang,James Varani,Sewon Kang,John J. Voorhees +6 more
TL;DR: It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).
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Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism
Jürgen Schauber,Robert A. Dorschner,Robert A. Dorschner,Alvin B. Coda,Alvin B. Coda,Amanda S. Büchau,Amanda S. Büchau,Philip T. Liu,David Kiken,David Kiken,Yolanda R. Helfrich,Sewon Kang,Hashem Z Elalieh,Andreas Steinmeyer,Ulrich Zügel,Daniel D. Bikle,Robert L. Modlin,Richard L. Gallo,Richard L. Gallo +18 more
TL;DR: What is believed to be a previously unexpected role for vitamin D3 in innate immunity is demonstrated, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection.
Journal ArticleDOI
Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.
James Varani,Michael K. Dame,Laure Rittié,Suzanne E.G. Fligiel,Sewon Kang,Gary J. Fisher,John J. Voorhees +6 more
TL;DR: It is concluded that reduced collagen synthesis in chronologically aged skin reflects at least two different underlying mechanisms: cellular fibroblast aging and a lower level of mechanical stimulation.