Showing papers in "Journal of Investigative Dermatology in 2002"

TL;DR: This review is to summarize recent progress in the understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic.

TL;DR: The current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes are discussed, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression.

TL;DR: Investigation of dendritic cell subsets in epidermal single cell suspensions of normal looking skin from healthy volunteers and of lesional skin from patients with different inflammatory skin diseases demonstrates that in addition to resident Langerhans cells, plasmacytoid dendrite cells and inflammatory dendrickal cells are selectively recruited to the skin lesions depending on the type of skin disease.

TL;DR: The correlation between photodamage and protein oxidation was demonstrated for the first time, which hence may be a relevant pathophysiologic factor in photoaging.

TL;DR: The study demonstrates the sensitivity of Raman spectroscopy to biochemical changes in tissue accompanying malignancy, resulting in a high accuracy when discriminating between basal cell carcinoma and noncancerous tissue.

TL;DR: It is confirmed that at micromolar concentrations human beta-defensin-2 has a broad spectrum of antimicrobial activity, with the striking exception of Staphylococcus aureus.

TL;DR: The demonstration of chemokine expression and receptor activation in melanoma tumor cells themselves, and the tumor infiltrating leukocytes, may have important implications in terms of tumor progression and tumor cell homing to metastatic sites.

TL;DR: Results indicate that cathelicidin is secreted in human sweat, has potent anti-microbial activity against both gram-positive and gram-negative bacteria, and can, after processing from the preproform, provide a barrier for protection against infection.

TL;DR: There is direct evidence that T lymphocytes present within the lesions of toxic epidermal necrolysis may exhibit, without any re-stimulation, a drug-specific cytotoxicity against autologous cells.

TL;DR: The results suggest the possibility that vulnerability to bacterial colonization in the skin of patients with atopic dermatitis is associated with reduced levels of a natural antimicrobial agent, sphingosine, which results from decreased levels of ceramides as a substrate and from diminished activities of its metabolic enzyme, acid ceramidase.

TL;DR: In this paper, the same six major enzyme systems are involved in cutaneous androgen metabolism, namely, steroid sulfatase, 3beta-hydroxy-steroid dehydrogenase, 17β-hydroxylase, steroid 5alpha-reductase, and 3alpha-hydrotestosterone to 3alphaandrostanediol glucuronide.

TL;DR: It is concluded that patients with psoriasis have different clinical features depending on whether they are HLA-Cw6 positive or negative.

TL;DR: The findings in this study suggest that the defective inhibitory regulation of desquamation due to the serine protease inhibitor Kazal-type 5 gene mutations may cause over-desquamation of corneocytes in Netherton syndrome, leading to severe skin permeability barrier dysfunction.

TL;DR: In the blood of cutaneous T cell lymphoma patients with peripheral blood involvement, there are significantly increased percentages of T cells displaying the skin-homing phenotype (CLA+CCR4+) compared with healthy individuals, which may explain, in part, why these T cells accumulate in the skin.

TL;DR: In conclusion, inflammatory dendritic epidermal cells but not Langerhans cells are expressing CD206 in situ and use it for receptor-mediated endocytotic activity.

TL;DR: It is revealed that the lesional epidermis in atopic dermatitis has considerable deficiencies within main barrier lipid components, which may contribute to the severely damaged permeability barrier.

TL;DR: The study indicates that the prevalence of hand eczema in Swedish adults had decreased between 1983 and 1996 despite an increasing prevalence of childhood Eczema, and a decreased occupational exposure to skin irritants is a probable cause.

TL;DR: It is demonstrated that human keratinocytes are capable of expressing functional CD14 and toll-like receptor 4 and this results have important implications for the understanding of cutaneous innate immunity to bacterial infections of the skin.

TL;DR: Results provide direct evidence that acute and sustained fluctuations in epidermal calcium regulate expression of differentiation-specific proteins in vivo, and demonstrate that modulations in epIDERmal calcium coordinately regulate events late in epidersmal differentiation that together form the barrier.

TL;DR: The evidence of a major genetic influence on acne should stimulate the search for potential genes that may lead to new therapeutic approaches, and the lower serum levels of apolipoprotein A1 in acne twins were confirmed when analyzing acne discordant twin pairs.

TL;DR: It is proposed that the role of aquaporin-3 is to water-clamp viable layers of the epidermis in order to improve the hydration of the Epidermis below the stratum corneum.

TL;DR: The clinical features of erythroderma, trichorrhexis invaginata, and atopic manifestations were present in the majority of affected individuals and ichthyosis linearis circumflexa was seen in 12 out of 24 patients, with no clear correlation between mutations and phenotype.

TL;DR: The temporal abnormalities between the two processes reflect the apparent lack of requirement for the vitamin D receptor during the anagen phase of the first (developmental) hair cycle, but with earlier effects on the terminal differentiation of the interfollicular epidermis.

TL;DR: Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increasedEpidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus, and the results suggest that stratum brachycephalic enzyme may be involved in the pathogenesis of inflammatory skin diseases.

TL;DR: In vitro results support the idea that autoantibodies to bullous pemphigoid 180 from patients with bullousPemphIGoid are of pathogenic relevance, and patients' sera purified against a recombinant form of bullouspemphicoid 180 NC16A retained their blister-inducing capacity, whereas patients' IgG depleted of reactivity to NC 16A lost this ability.

TL;DR: It is demonstrated that exfoliative toxin A and exfoluative toxin B cause blister formation in staphylococcal scalded skin syndrome and bullous impetigo by identical molecular pathophysiologic mechanisms.

TL;DR: The expression of MIC is reported in 31 of 40 primary cutaneous melanomas and in 13 of 20 metastatic lesions and lymphocytes infiltrating the tumor were found to express NKG2D.

TL;DR: The anti-inflammatory properties of peroxisome proliferator activated receptor-alpha agonists, coupled with their anti-proliferative and pro-differentiating effects, suggest that they could be beneficial for the treatment of a variety of cutaneous diseases.

TL;DR: It is demonstrated that halofuginone is a specific inhibitor of type-I collagen synthesis and may elicit its effect via interference with the transforming growth factor beta signaling pathway.