T
Tim W. Gilberger
Researcher at Bernhard Nocht Institute for Tropical Medicine
Publications - 44
Citations - 2064
Tim W. Gilberger is an academic researcher from Bernhard Nocht Institute for Tropical Medicine. The author has contributed to research in topics: Plasmodium falciparum & Inner membrane complex. The author has an hindex of 25, co-authored 42 publications receiving 1782 citations. Previous affiliations of Tim W. Gilberger include McMaster University & University of Hamburg.
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Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
Rebecca A. O'Donnell,Fiona Hackett,Steven Howell,Moritz Treeck,Nicole S. Struck,Zita Krnajski,Chrislaine Withers-Martinez,Tim W. Gilberger,Michael J. Blackman +8 more
TL;DR: A crucial role for intramembrane proteolysis in the life cycle of this pathogen is identified and mutations within the EBA-175 TMD that abolish cleavage by PfROM4 prevent parasite growth.
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Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process
Moritz Treeck,Sonja Zacherl,Susann Herrmann,Ana Cabrera,Maya Kono,Nicole S. Struck,Klemens Engelberg,Silvia Haase,Friedrich Frischknecht,Kota Miura,Tobias Spielmann,Tim W. Gilberger +11 more
TL;DR: Mutational analysis suggests an important role for the phosphorylation in the invasion process of Plasmodium falciparum, which might translate into novel therapeutic strategies.
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Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite.
Kerstin Leykauf,Moritz Treeck,Paul R. Gilson,Thomas Nebl,Thomas Braulke,Alan F. Cowman,Tim W. Gilberger,Tim W. Gilberger,Brendan S. Crabb,Brendan S. Crabb,Brendan S. Crabb +10 more
TL;DR: This work provides evidence that the enzyme responsible for serine 610 phosphorylation is the cAMP regulated protein kinase A (PfPKA), and represents the first time PKA has been implicated in merozoite invasion.
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Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite
Maya Kono,Susann Herrmann,Noeleen B. Loughran,Ana Cabrera,Klemens Engelberg,Christine Lehmann,Dipto Sinha,Boris Prinz,Ulrike Ruch,Volker Heussler,Volker Heussler,Tobias Spielmann,John Parkinson,Tim W. Gilberger +13 more
TL;DR: It is revealed that the IMC is an essential structural compartment for the development of the sexual stages of Plasmodium, as it seems to drive the morphological changes of the parasite during the long and multistaged process of sexual differentiation.
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Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II.
Katherine E. Jackson,Tobias Spielmann,Tobias Spielmann,Eric Hanssen,Akinola Adisa,Frances Separovic,Matthew W. A. Dixon,Katharine R. Trenholme,Paula L. Hawthorne,Donald L. Gardiner,Tim W. Gilberger,Leann Tilley +11 more
TL;DR: Novel tools for the analysis of this important human pathogen are provided and differences between Plasmodium-infected and uninfected RBCs are highlighted.