J
John Parkinson
Researcher at University of Toronto
Publications - 351
Citations - 19993
John Parkinson is an academic researcher from University of Toronto. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Microbiome. The author has an hindex of 66, co-authored 333 publications receiving 18225 citations. Previous affiliations of John Parkinson include University of Strathclyde & Cardiff University.
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Journal ArticleDOI
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Nevan J. Krogan,Gerard Cagney,Gerard Cagney,Haiyuan Yu,Gouqing Zhong,Xinghua Guo,Alexandr Ignatchenko,Joyce Li,Shuye Pu,Nira Datta,Aaron Tikuisis,Thanuja Punna,José M. Peregrín-Alvarez,Michael Shales,Xin Zhang,Michael Davey,Mark D. Robinson,Alberto Paccanaro,James E. Bray,Anthony Sheung,Bryan Beattie,Dawn Richards,Veronica Canadien,Atanas Iliev Lalev,Frank Mena,Peter D Wong,Andrei Starostine,Myra M. Canete,James Vlasblom,Samuel Wu,Chris Orsi,Sean R. Collins,Shamanta Chandran,Robin Haw,Jennifer J. Rilstone,Kiran Gandi,Natalie J. Thompson,Gabe Musso,Peter St Onge,Shaun Ghanny,Mandy H. Y. Lam,Gareth Butland,Amin M. Altaf-Ul,Shigehiko Kanaya,Ali Shilatifard,Erin K. O'Shea,Jonathan S. Weissman,C. James Ingles,Timothy P. Hughes,John Parkinson,Mark Gerstein,Shoshana J. Wodak,Andrew Emili,Jack Greenblatt +53 more
TL;DR: T tandem affinity purification was used to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae to identify protein–protein interactions, which will help future studies on individual proteins as well as functional genomics and systems biology.
Journal ArticleDOI
Interaction network containing conserved and essential protein complexes in Escherichia coli
Gareth Butland,José M. Peregrín-Alvarez,Joyce Li,Wehong Yang,Xiaochun Yang,Veronica Canadien,Andrei Starostine,Dawn Richards,Bryan Beattie,Nevan J. Krogan,Michael Davey,John Parkinson,John Parkinson,Jack Greenblatt,Andrew Emili +14 more
TL;DR: Insight is provided into the function of previously uncharacterized bacterial proteins and the overall topology of a microbial interaction network, the core components of which are broadly conserved across Prokaryota.
Journal ArticleDOI
Draft Genome of the Filarial Nematode Parasite Brugia malayi
Elodie Ghedin,Elodie Ghedin,Shiliang Wang,David J. Spiro,Elisabet Caler,Qi Zhao,Jonathan Crabtree,Jonathan E. Allen,Arthur L. Delcher,David B. Guiliano,Diego Miranda-Saavedra,Samuel V. Angiuoli,Todd Creasy,Paolo Amedeo,Brian J. Haas,Najib M. El-Sayed,Jennifer R. Wortman,Tamara Feldblyum,Luke J. Tallon,Michael C. Schatz,Martin Shumway,Hean Koo,Steven L. Salzberg,Seth Schobel,Mihaela Pertea,Mihai Pop,Owen White,Geoffrey J. Barton,Clotilde K. S. Carlow,Crawford Michael J,Jennifer Daub,Dimmic Matt W,Chris F. Estes,Jeremy M. Foster,Mehul B. Ganatra,William F. Gregory,Nicholas M. Johnson,Jinming Jin,Richard Komuniecki,Ian F Korf,Sanjay Kumar,Sandra J. Laney,Ben-Wen Li,Wen Li,Tim H. Lindblom,Sara Lustigman,Dong Ma,Claude V. Maina,David M. A. Martin,James P. McCarter,Larry A. McReynolds,Makedonka Mitreva,Thomas B. Nutman,John Parkinson,José M. Peregrín-Alvarez,Catherine B. Poole,Qinghu Ren,Lori Saunders,Ann E. Sluder,Katherine A. Smith,Mario Stanke,Thomas R. Unnasch,Jenna Ware,Aguan Wei,Gary J. Weil,Deryck J. Williams,Yinhua Zhang,Steven A. Williams,Claire M. Fraser-Liggett,Barton E. Slatko,Mark Blaxter,Alan L. Scott +71 more
TL;DR: In this article, the authors sequenced the ∼90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predicted ∼11,500 protein coding genes in 71 Mb of robustly assembled sequence.
Journal ArticleDOI
The genomes of four tapeworm species reveal adaptations to parasitism
Isheng J. Tsai,Magdalena Zarowiecki,Nancy Holroyd,Alejandro Garciarrubio,Alejandro Sanchez-Flores,Karen Brooks,Alan Tracey,Raúl J. Bobes,Gladis Fragoso,Edda Sciutto,Martin Aslett,Helen Beasley,Hayley M. Bennett,Jianping Cai,Federico Camicia,Richard Clark,Marcela Alejandra Cucher,Nishadi De Silva,Tim A. Day,Peter Deplazes,Karel Estrada,Cecilia Fernández,Peter W. H. Holland,Junling Hou,Songnian Hu,Thomas Huckvale,Stacy S. Hung,Laura Kamenetzky,Jacqueline A. Keane,Ferenc Kiss,Uriel Koziol,Olivia Lambert,Kan Liu,Xuenong Luo,Yingfeng Luo,Natalia Macchiaroli,Sarah Nichol,Jordi Paps,John Parkinson,Natasha Pouchkina-Stantcheva,Nick Riddiford,Mara Cecilia Rosenzvit,Gustavo Salinas,James D. Wasmuth,Mostafa Zamanian,Yadong Zheng,Xuepeng Cai,Xavier Soberón,Peter D. Olson,Juan Pedro Laclette,Klaus Brehm,Matthew Berriman +51 more
TL;DR: An analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma offers insights into the evolution of parasitism and identifies new potential drug targets.
Journal ArticleDOI
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan,Cuihong Wan,Blake Borgeson,Sadhna Phanse,Fan Tu,Kevin Drew,Greg W. Clark,Xuejian Xiong,Olga Kagan,Julian Kwan,Alexandr Bezginov,Kyle Chessman,Swati Pal,Graham L. Cromar,Ophelia Papoulas,Zuyao Ni,Daniel R. Boutz,Snejana Stoilova,Pierre C. Havugimana,Xinghua Guo,Ramy H. Malty,Mihail Sarov,Jack Greenblatt,Mohan Babu,W. Brent Derry,Elisabeth R. M. Tillier,John B. Wallingford,John Parkinson,Edward M. Marcotte,Andrew Emili +29 more
TL;DR: A draft conservation map is generated consisting of more than one million putative high-confidence co-complex interactions for species with fully sequenced genomes that encompasses functional modules present broadly across all extant animals.