T
Timothy E. Richardson
Researcher at University of Texas Health Science Center at San Antonio
Publications - 89
Citations - 1159
Timothy E. Richardson is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 61 publications receiving 727 citations. Previous affiliations of Timothy E. Richardson include State University of New York Upstate Medical University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Sohlh2 Knockout Mice Are Male-Sterile Because of Degeneration of Differentiating Type A Spermatogonia
Jing Hao,Miwako Yamamoto,Timothy E. Richardson,Karen M. Chapman,Bray Denard,Robert E. Hammer,Guang Quan Zhao,F. Kent Hamra +7 more
TL;DR: One conclusion originating from these studies would be that testicular factors normally regulate the viability of differentiating spermatogonia by signaling through Sohlh2, which would provide a crucial checkpoint to optimize the numbers of sperMatocytes entering meiosis during each cycle of sPermatogenesis.
Journal ArticleDOI
Spermatogonial Culture Medium: An Effective and Efficient Nutrient Mixture for Culturing Rat Spermatogonial Stem Cells
Zhuoru Wu,Ilaria Falciatori,Laura A. Molyneux,Timothy E. Richardson,Karen M. Chapman,F. Kent Hamra +5 more
TL;DR: Spermatogonial lines derived and propagated using SG medium were characterized as homogeneous populations of ZBTB16+ DAZL+ cells endowed with sperMatogonial stem cell potential, which transmitted the donor cell haplotype to more than 75% of progeny by natural breeding.
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Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.
Maxim Signaevsky,Marcel Prastawa,Kurt Farrell,Nabil Tabish,Elena Baldwin,Natalia Han,Megan A. Iida,John Koll,Clare Bryce,Dushyant P. Purohit,Vahram Haroutunian,Vahram Haroutunian,Ann C. McKee,Thor D. Stein,Charles L. White,Jamie M. Walker,Timothy E. Richardson,Russell W. Hanson,Michael J. Donovan,Carlos Cordon-Cardo,Jack Zeineh,Gerardo Fernandez,John F. Crary +22 more
TL;DR: It is found that the deep learning framework is capable of identifying and quantifying NFT with a range of staining intensities and diverse morphologies, and is efficient and well suited for the practical application of WSIs with average processing times of 45 min per WSI per GPU.
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An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation.
Kimberly M. Lincoln,Timothy E. Richardson,Lauren Rutter,Paulina Gonzalez,James W. Simpkins,Kayla N. Green +5 more
TL;DR: Spectroscopic, transmission electron microscopy, and scanning electron microscope imaging studies show that 1 (pyclen) is capable of both preventing and disrupting Cu(2+) induced AB(1-40) aggregation and the pyridine backbone is responsible for the antioxidant capacity observed.
Journal ArticleDOI
Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts
TL;DR: It is demonstrated that phenolic estrogens, independent of any known ER, are able to prevent lipid peroxidation and mitochondrial membrane potential (ΔΨm) collapse, maintain ATP at near control levels, increase oxidative phosphorylation and maintain activity of aconitase.