T
Timothy R. O'Connor
Researcher at University of Queensland
Publications - 17
Citations - 2546
Timothy R. O'Connor is an academic researcher from University of Queensland. The author has contributed to research in topics: Gene & Chromatin immunoprecipitation. The author has an hindex of 13, co-authored 17 publications receiving 2362 citations. Previous affiliations of Timothy R. O'Connor include Microsoft & Washington State University.
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Journal ArticleDOI
The importance of intrinsic disorder for protein phosphorylation
Lilia M. Iakoucheva,Predrag Radivojac,Celeste J. Brown,Celeste J. Brown,Timothy R. O'Connor,Jason G. Sikes,Zoran Obradovic,A. Keith Dunker +7 more
TL;DR: A new web-based tool for the prediction of protein phosphorylation sites, DISPHOS (DISorder-enhanced PHOSphorylation predictor, http://www.ist. edu/DISPHOS), which observes that amino acid compositions, sequence complexity, hydrophobicity, charge and other sequence attributes of regions adjacent to phosphate sites are very similar to those of intrinsically disordered protein regions.
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Defining the RGG/RG Motif
TL;DR: The role of the RGG/RG motif in mediating nucleic acid and protein interactions, a function that is often regulated by arginine methylation and partner-binding proteins, is discussed.
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Athena: a resource for rapid visualization and systematic analysis of Arabidopsis promoter sequences
TL;DR: The Athena database, which contains 30,067 predicted Arabidopsis promoter sequences and consensus sequences for 105 previously characterized transcription factor (TF) binding sites, is developed.
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Calmodulin signaling: Analysis and prediction of a disorder-dependent molecular recognition
Predrag Radivojac,Slobodan Vucetic,Timothy R. O'Connor,Vladimir N. Uversky,Zoran Obradovic,A. Keith Dunker +5 more
TL;DR: A predictor of CaM‐binding regions was developed and per residue accuracy of this predictor reached 81%, which, in combination with a high recall/precision balance at the binding region level, suggests high predictability of Ca M‐binding partners.
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Human thymine DNA glycosylase (TDG) and methyl‐CpG‐binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair
TL;DR: It is shown that TDG and MBD4 can remove thymine glycol when present opposite guanine but not when paired with adenine, which indicates that this repair pathway contributes to mutation avoidance at methylated CpG dinucleotides.