T
Tobias Hirsch
Researcher at Ruhr University Bochum
Publications - 137
Citations - 3376
Tobias Hirsch is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Gene delivery & Soft tissue sarcoma. The author has an hindex of 28, co-authored 124 publications receiving 2854 citations. Previous affiliations of Tobias Hirsch include Harvard University & Heidelberg University.
Papers
More filters
Journal ArticleDOI
Regeneration of the entire human epidermis using transgenic stem cells
Tobias Hirsch,Tobias Rothoeft,Norbert Teig,Johann W. Bauer,Graziella Pellegrini,Laura De Rosa,Davide Scaglione,Julia Reichelt,Alfred Klausegger,Daniela Kneisz,Oriana Romano,Alessia Secone Seconetti,Roberta Contin,Elena Enzo,Irena Jurman,Sonia Carulli,Frank Jacobsen,Thomas Luecke,Marcus Lehnhardt,Meike Fischer,Maximilian Kueckelhaus,Daniela Quaglino,Michele Morgante,Silvio Bicciato,Sergio Bondanza,Michele De Luca +25 more
TL;DR: It is shown that autologous transgenic keratinocyte cultures regenerated an entire, fully functional epidermis on a seven-year-old child suffering from a devastating, life-threatening form of JEB, providing a blueprint that can be applied to other stem cell-mediated combined ex vivo cell and gene therapies.
Journal ArticleDOI
Host defense peptides in wound healing.
Lars Steinstraesser,Till Koehler,Frank Jacobsen,Adrien Daigeler,Ole Goertz,Stefan Langer,Marco R. Kesting,Hans U. Steinau,Elof Eriksson,Tobias Hirsch,Tobias Hirsch +10 more
TL;DR: This review focuses on the current knowledge of host defense peptides affecting wound healing and infection and discusses the current data and the potential future developments in this field of research.
Journal ArticleDOI
Human beta-defensin-3 promotes wound healing in infected diabetic wounds.
Tobias Hirsch,Malte Spielmann,Malte Spielmann,Baraa Zuhaili,Magdalena Fossum,Marie Metzig,Marie Metzig,Till Koehler,Hans U. Steinau,Feng Yao,Andrew B. Onderdonk,Lars Steinstraesser,Elof Eriksson +12 more
TL;DR: The present study aimed to analyse the effect of hBD‐3 expression in a model of infected diabetic wounds to study the role of human beta‐defensin in the immune response.
Journal ArticleDOI
Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection
Lars Steinstraesser,Tobias Hirsch,Matthias Schulte,Maximilian Kueckelhaus,Frank Jacobsen,Evgenija A. Mersch,Ingo Stricker,Nicole Afacan,Håvard Jenssen,Robert E. W. Hancock,Jason Kindrachuk +10 more
TL;DR: This investigation demonstrates that in addition to previously reported immunomodulatory activities IDR-1018 promotes wound healing independent of direct antibacterial activity, these effects were not observed in diabetic wounds.
Journal ArticleDOI
Enhanced susceptibility to infections in a diabetic wound healing model
Tobias Hirsch,Tobias Hirsch,Malte Spielmann,Malte Spielmann,Baraa Zuhaili,Till Koehler,Till Koehler,Magdalena Fossum,Hans-Ulrich Steinau,Feng Yao,Lars Steinstraesser,Andrew B. Onderdonk,Elof Eriksson +12 more
TL;DR: A novel wound healing model suitable for monitoring the development and effect of bacterial infections in diabetic wounds is developed to closely assess infections during diabetic wound healing and to monitor the effect of therapeutical agents in vivo.