Davide Scaglione

TL;DR: It is shown that autologous transgenic keratinocyte cultures regenerated an entire, fully functional epidermis on a seven-year-old child suffering from a devastating, life-threatening form of JEB, providing a blueprint that can be applied to other stem cell-mediated combined ex vivo cell and gene therapies.

TL;DR: The use of the manual annotation tool WebApollo facilitated manual checking and correction of gene models enabling improvement of computational prediction, especially relevant for certain types of gene families such as the EXPANSIN like genes.

TL;DR: The data suggest that the basic gene network controlling fruit ripening is conserved in different Solanaceae clades, and that climacteric Fruit ripening involves a differential regulation of relatively few components of this network, including CNR and ethylene biosynthetic genes.

TL;DR: The RAD tag sequencing approach is a cost-effective and rapid method to develop SNP markers in a highly heterozygous species and permitted to generate a large and robust SNP datasets by the adoption of optimized filtering criteria.

TL;DR: The extremely low levels of variation observed in the species, as a consequence of the polyploidization event, make the exploitation of diversity within the species for breeding purposes less interesting than in most crop species and stress the need for introgression of new variability from the diploid progenitors.