T
Todd A. Sangster
Researcher at University of Chicago
Publications - 11
Citations - 2350
Todd A. Sangster is an academic researcher from University of Chicago. The author has contributed to research in topics: Genetic variation & Evolutionary capacitance. The author has an hindex of 10, co-authored 11 publications receiving 2225 citations. Previous affiliations of Todd A. Sangster include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Hsp90 as a capacitor of phenotypic variation
TL;DR: It is reported that, in Arabidopsis accessions and recombinant inbred lines, reducing Hsp90 function produces an array of morphological phenotypes, which are dependent on underlying genetic variation, and that HSp90 influences morphogenetic responses to environmental cues and buffers normal development from destabilizing effects of stochastic processes.
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Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance.
TL;DR: Proper protein folding crucially affects the trajectory from genotype to phenotype and the impact of protein quality‐control mechanisms and other fundamental cellular processes on evolution has heretofore been overlooked.
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HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
Todd A. Sangster,Neeraj Salathia,Soledad F. Undurraga,Ron Milo,Kurt Schellenberg,Susan Lindquist,Christine Queitsch +6 more
TL;DR: It is demonstrated that HSP90-dependent alleles occur in continuously distributed, environmentally responsive traits and are amenable to quantitative genetic mapping techniques, and it is found that developmental stability is a phenotypic trait that can be affected by natural variation.
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The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity.
TL;DR: Plants have emerged as powerful tools that complement other model systems in attempts to extend the authors' knowledge of the myriad impacts of protein folding and chaperone function and HSP90 is crucial for R-protein-mediated defense against pathogens.
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Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels.
Todd A. Sangster,Adam K. Bahrami,Amity M. Wilczek,Etsuko Watanabe,Kurt Schellenberg,Catherine A. McLellan,Alicia Kelley,Sek Won Kong,Christine Queitsch,Susan Lindquist +9 more
TL;DR: HSP90 exerts global effects on the environmental responsiveness of plants to many different stimuli, and genome-wide expression analyses suggest a central role for HSP90 in the genesis and maintenance of plastic responses.