T
Tom H. Cheung
Researcher at Hong Kong University of Science and Technology
Publications - 53
Citations - 4483
Tom H. Cheung is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Stem cell & Adult stem cell. The author has an hindex of 21, co-authored 44 publications receiving 3505 citations. Previous affiliations of Tom H. Cheung include Stanford University & University of Colorado Boulder.
Papers
More filters
Journal ArticleDOI
Molecular regulation of stem cell quiescence
TL;DR: Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase the understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.
Journal ArticleDOI
Notch signaling is necessary to maintain quiescence in adult muscle stem cells.
Christopher R. R. Bjornson,Tom H. Cheung,Ling Liu,Pinky V. Tripathi,Katherine M. Steeper,Thomas A. Rando,Thomas A. Rando +6 more
TL;DR: The requirement of Notch signaling for the maintenance of the quiescent state and for muscle stem cell homeostasis by the regulation of self‐renewal and differentiation, processes that are all critical for normal postnatal myogenesis are demonstrated.
Journal ArticleDOI
Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging
Ling Liu,Tom H. Cheung,Gregory W. Charville,Bernadette Marie Ceniza Hurgo,Tripp Leavitt,Johnathan Shih,Anne-Christine Brunet,Thomas A. Rando,Thomas A. Rando +8 more
TL;DR: It is shown that QSCs possess a permissive chromatin state in which few genes are epigenetically repressed by Polycomb group (PcG)-mediated histone 3 lysine 27 trimethylation, and a large number of genes encoding regulators that specify nonmyogenic lineages are demarcated by bivalent domains at their transcription start sites.
Journal ArticleDOI
Maintenance of muscle stem-cell quiescence by microRNA-489
Tom H. Cheung,Navaline L. Quach,Gregory W. Charville,Ling Liu,Lidia Park,Abdolhossein Edalati,Bryan B. Yoo,Phuong T. Hoang,Thomas A. Rando +8 more
TL;DR: Evidence is provided of the miRNA pathway in general, and of a specific miRNA, miR-489, in actively maintaining the quiescent state of an adult stem-cell population, as it functions as a regulator of satellite-cell quiescence.
Journal ArticleDOI
Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting
TL;DR: This protocol provides a detailed description of the physical and enzymatic dissociation of mononucleated cells from limb muscles, a procedure that is essential in order to maximize cell yield, and describes a FACS-based method that is used subsequently to obtain highly pure populations of either quiescent or activated MuSCs.