T
Tom W. Muir
Researcher at Princeton University
Publications - 301
Citations - 27097
Tom W. Muir is an academic researcher from Princeton University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 82, co-authored 290 publications receiving 24282 citations. Previous affiliations of Tom W. Muir include University of Edinburgh & University of Wisconsin-Madison.
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Synthesis of proteins by native chemical ligation
TL;DR: The technique of native chemical ligation is employable for chemically synthesizing full length proteins as discussed by the authors, which are chemically identical to proteins produced by cell free synthesis, and can be refolded and/or oxidized to form native disulfide-containing protein molecules.
Journal ArticleDOI
Expressed protein ligation: A general method for protein engineering
TL;DR: This work illustrates that expressed protein ligation is a simple and powerful new method in protein engineering to introduce sequences of unnatural amino acids, posttranslational modifications, and biophysical probes into proteins of any size.
Journal ArticleDOI
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Peter W. Lewis,Manuel M. Müller,Matthew S. Koletsky,Francisco Cordero,Shu Lin,Laura A. Banaszynski,Benjamin A. Garcia,Tom W. Muir,Oren J. Becher,C. David Allis +9 more
TL;DR: It is proposed that K-to-M substitutions may represent a mechanism to alter epigenetic states in a variety of pathologies and be sufficient to cause specific reduction in methylation through inhibition of SET-domain enzymes.
Journal ArticleDOI
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann,Andres Gaytan de Ayala Alonso,Katarzyna Oktaba,Nga Ly-Hartig,Robert K. McGinty,Sven Fraterman,Matthias Wilm,Tom W. Muir,Jürg Müller +8 more
TL;DR: It is shown that the uncharacterized Drosophila PcG gene calypso encodes the ubiquitin carboxy-terminal hydrolase BAP1, and Polycomb gene silencing may entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H 2A deubiquitinationBy PR-DUB.
Journal ArticleDOI
Semisynthesis of Proteins by Expressed Protein Ligation
TL;DR: In this review, the development of this technology is discussed, its broad application to biological systems, and its possible role in the area of proteomics are discussed.