K
Katarzyna Oktaba
Researcher at European Bioinformatics Institute
Publications - 14
Citations - 2064
Katarzyna Oktaba is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Chromatin & Polycomb-group proteins. The author has an hindex of 9, co-authored 12 publications receiving 1902 citations. Previous affiliations of Katarzyna Oktaba include National Autonomous University of Mexico & University of California, Berkeley.
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Journal ArticleDOI
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann,Andres Gaytan de Ayala Alonso,Katarzyna Oktaba,Nga Ly-Hartig,Robert K. McGinty,Sven Fraterman,Matthias Wilm,Tom W. Muir,Jürg Müller +8 more
TL;DR: It is shown that the uncharacterized Drosophila PcG gene calypso encodes the ubiquitin carboxy-terminal hydrolase BAP1, and Polycomb gene silencing may entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H 2A deubiquitinationBy PR-DUB.
Journal ArticleDOI
Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression
TL;DR: It is found that the Drosophila Polycomb group gene super sex combs encodes Ogt, the highly conserved glycosyltransferase that catalyzes the addition of N-acetylglucosamine (GlcNAc) to proteins in animals and plants.
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
Maxim Nekrasov,Tetyana Klymenko,Sven Fraterman,Bernadett Papp,Katarzyna Oktaba,Adrian Cohen,Hendrik G. Stunnenberg,Matthias Wilm,Jürg Müller +8 more
TL;DR: Analysis of Drosophila mutants that lack Pcl unexpectedly reveals that Pcl‐PRC2 is required to generate high levels of H3‐K27 trimethylation at Polycomb target genes but is dispensable for the genome‐wide H3-K27 mono‐ and dimethylation that is generated by PRC2.
Journal ArticleDOI
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
Maxim Nekrasov,Tetyana Klymenko,Sven Fraterman,Bernadett Papp,Katarzyna Oktaba,Thomas Köcher,Adrian Cohen,Hendrik G. Stunnenberg,Matthias Wilm,Jürg Müller +9 more
TL;DR: In this article, the biochemical purification and characterization of a distinct form of Drosophila PRC2 that contains the Polycomb group protein polycomblike (Pcl).
Journal ArticleDOI
Dynamic Regulation by Polycomb Group Protein Complexes Controls Pattern Formation and the Cell Cycle in Drosophila
Katarzyna Oktaba,Luis Gutiérrez,Julien Gagneur,Charles Girardot,Aditya K. Sengupta,Eileen E. M. Furlong,Jürg Müller +6 more
TL;DR: In this article, genome-wide binding profiles of PhoRC, the Drosophila PcG protein complex containing the DNA-binding factor Pho/dYY1 and dSfmbt were reported.