Tomas Sou

TL;DR: The results suggest that with suitable particle size, good dispersibility and solid-state properties, selected trehalose/leucine combinations appear to have good potential for development into a universal carrier platform for pulmonary delivery of potent biomacromolecules.

TL;DR: The current understanding of pulmonary immunization is described, including possible barriers facing the development of pulmonary vaccines, and recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery are discussed.

TL;DR: The results show that the use of glycine and/or alanine, though structurally related to leucine, did not achieve similar aerosol performance enhancing effects, rather the particle formation was hindered and the lack of linearity of effects for certain responses with a significant curvature in the model was revealed.

TL;DR: The usability of the spray-dried carrier as a promising platform for pulmonary delivery of influenza vaccine was demonstrated and the potential utility of this delivery system for other biomacromolecules may also be further explored.

TL;DR: In this paper, the use of a range of polymers for the production of an amorphous glassy carrier platform for pulmonary delivery of potent biomacromolecules was investigated.