M
Michelle P. McIntosh
Researcher at Monash University
Publications - 82
Citations - 2497
Michelle P. McIntosh is an academic researcher from Monash University. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 26, co-authored 82 publications receiving 2130 citations. Previous affiliations of Michelle P. McIntosh include University of Kansas & University of Liverpool.
Papers
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Journal ArticleDOI
Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization.
Aisha Qi,James Friend,Leslie Y. Yeo,David Alexander Vodden Morton,Michelle P. McIntosh,Leone Spiccia +5 more
TL;DR: Control offered over the aerosol size, low power requirements, high delivery efficiency, and the miniaturization of the system together suggest the proposed platform represents an attractive alternative to current nebulizers compatible with microfluidic technologies.
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Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration
Shalini Wickramaratne Senarath Yapa,Jian Li,Kashyap Patel,John W Wilson,Michael J. Dooley,Johnson George,D. Clark,Susan Poole,E. Williams,Christopher J.H. Porter,Roger L. Nation,Michelle P. McIntosh +11 more
TL;DR: Inhalation of CMS is an effective means of targeting CMS and formed colistin for delivery to the lungs, as high lung exposure and minimal systemic exposure were achieved in CF subjects.
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Lipid Digestion as a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems
Mette Uhre Anby,Hywel David Williams,Michelle P. McIntosh,Hassan Benameur,Glenn A. Edwards,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The data suggest that digestion acts as a "trigger" for enhanced supersaturation and that solubilization/precipitation behavior is correlated with the degree of supersaturation on dispersion (S(M)DISP) or digestion (S (M)DIGEST).
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The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules
Tomas Sou,Lisa M. Kaminskas,Tri-Hung Nguyen,Renee Carlberg,Michelle P. McIntosh,David Alexander Vodden Morton +5 more
TL;DR: The results suggest that with suitable particle size, good dispersibility and solid-state properties, selected trehalose/leucine combinations appear to have good potential for development into a universal carrier platform for pulmonary delivery of potent biomacromolecules.
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New developments in dry powder pulmonary vaccine delivery
Tomas Sou,Elza Nicole Theresia Meeusen,Michael John de Veer,David Alexander Vodden Morton,Lisa M. Kaminskas,Michelle P. McIntosh +5 more
TL;DR: The current understanding of pulmonary immunization is described, including possible barriers facing the development of pulmonary vaccines, and recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery are discussed.