T
Tomasz Szczepański
Researcher at Medical University of Silesia
Publications - 267
Citations - 10296
Tomasz Szczepański is an academic researcher from Medical University of Silesia. The author has contributed to research in topics: Minimal residual disease & Gene rearrangement. The author has an hindex of 47, co-authored 238 publications receiving 8935 citations. Previous affiliations of Tomasz Szczepański include University of Silesia in Katowice & Wrocław Medical University.
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Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL.
Małgorzata Dawidowska,Maria Kosmalska,Łukasz Sędek,Aleksandra Szczepankiewicz,Magdalena Twardoch,Alicja Sonsala,Bronisława Szarzyńska-Zawadzka,Katarzyna Derwich,Monika Lejman,Katarzyna Pawelec,Agnieszka Obitko-Płudowska,Katarzyna Pawińska-Wąsikowska,Kinga Kwiecińska,Andrzej Kołtan,Agnieszka Dyla,Władysław Grzeszczak,Jerzy Kowalczyk,Tomasz Szczepański,Ewa Ziętkiewicz,Michał Witt +19 more
TL;DR: Germline variation in genes related to pharmacokinetics/pharmacodynamics of anti-leukemic drugs and to anti-tumor immunity of the host is associated with MRD status and might help improve risk assessment in ALL.
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Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia.
Jan Styczyński,Mariusz Wysocki,Robert Dębski,Edyta Juraszewska,Iwona Malinowska,Elzbieta Stanczak,Anna Płoszyńska,Jolanta Stefaniak,Benigna Mazur,Tomasz Szczepański +9 more
TL;DR: This study shows that no drug was found which, on average, was more effective in AML than in ALL samples, and the sensitivity of myeloblasts to platinum derivatives might have prognostic value.
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Outcome of Infants Less Than One Year of Age with Acute Lymphoblastic Leukemia Treated with the Interfant-99 Protocol.
Rob Pieters,Martin Schrappe,P De Lorenzo,Ian Hann,Ajay Vora,G. deRossi,Andrea Biondi,Maria S. Felice,Liisa Hovi,Francoise Mechinaud,Tomasz Szczepański,Alina Ferster,Gritta Janka,Jeffrey E. Rubnitz,Lewis B. Silverman,J. Stary,Myriam Campbell,Georg Mann,Ram Suppiah,M. G. Valsecchi +19 more
TL;DR: Cox model showed that MLL rearrangement and age 300x10e9/L and poor prednisone response were also of independent prognostic value within infant ALL, indicating that early treatment intensification is necessary.
Surgical management in patients with aneurysmal subarachnoid hemorrhage. The outcomes in the paradigm shift period.
TL;DR: The introduction of endovascular methods in the treatment of patients with aneurismal SAH resulted in an almost halving of the number of patients treated surgically and GCS has a better predictive value for outcomes in patients withAneurysmal SAH than the commonly-used WFNS and Hunt-Hess scales.
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Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia.
Joanna Zawitkowska,Monika Lejman,Michał Romiszewski,Michał Matysiak,Magdalena Ćwiklińska,Walentyna Balwierz,Joanna Owoc-Lempach,Bernarda Kazanowska,Katarzyna Derwich,Jacek Wachowiak,Maciej Niedźwiecki,Elżbieta Adamkiewicz-Drożyńska,Joanna Trelińska,Wojciech Młynarski,Andrzej Kołtan,Mariusz Wysocki,Renata Tomaszewska,Tomasz Szczepański,Marcin Płonowski,Maryna Krawczuk-Rybak,Justyna Urbańska-Rakus,Katarzyna Machnik,Tomasz Ociepa,Tomasz Urasiński,Agnieszka Mizia-Malarz,Grażyna Sobol-Milejska,Grażyna Karolczyk,Jerzy Kowalczyk +27 more
TL;DR: The study shows that the ALL IC-BFM 2009 protocol improved the results of children with ALL compared to the ALLIC 2002 protocol in Poland, and confirms that MRD marrow assessment on day 15 of treatment by FCM-MRD is an important predictive factor.