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Tommy Cedervall
Researcher at Lund University
Publications - 71
Citations - 11816
Tommy Cedervall is an academic researcher from Lund University. The author has contributed to research in topics: Protein Corona & Nanoparticle. The author has an hindex of 27, co-authored 64 publications receiving 10072 citations. Previous affiliations of Tommy Cedervall include University College Dublin & Haverford College.
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Journal ArticleDOI
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
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Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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The Evolution of the Protein Corona around Nanoparticles: A Test Study
Martin Lundqvist,Martin Lundqvist,Johannes Stigler,Tommy Cedervall,Tord Berggård,Michelle B. Flanagan,Iseult Lynch,Giuliano Elia,Kenneth A. Dawson +8 more
TL;DR: The results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history, which could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.
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Detailed identification of plasma proteins adsorbed on copolymer nanoparticles.
Tommy Cedervall,Iseult Lynch,Martina Foy,Tord Berggård,Seamas C. Donnelly,Gerard Cagney,Sara Linse,Kenneth A. Dawson +7 more
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The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century.
Iseult Lynch,Tommy Cedervall,Martin Lundqvist,Celia Cabaleiro-Lago,Sara Linse,Kenneth A. Dawson +5 more
TL;DR: It is argued that in a biological fluid, proteins associate with nanoparticles, and it is the amount and presentation of the proteins on the surface rather than the particles themselves that are the cause of numerous biological responses.