Tommy Cedervall

TL;DR: It is observed that cholesterol and triglycerides effectively bind to NP emphasizing that proteins are not the only biomolecules with high-affinity binding to nanomaterial surfaces and that further knowledge on NP interactions with mouse serum is necessary regarding the common use of this model to predict the in vivo efficiency of NP.

TL;DR: Investigation of the structural consequences of the adsorption of apoAI, apolipoprotein B100 (apoB100), and HDL on polystyrene nanoparticles with different surface charges finds surface charge is a critical parameter for predicting structural changes in adsorbed proteins, yet the effect is specific for each protein.

TL;DR: It is demonstrated that low concentrations of 20 and 80 nm sized Ag- and AuNPs have adverse effects on the retina, using an organotypic retina culture model, to motivate careful assessment of candidate NP, metallic or-non-metallic, to be used in neural systems for therapeutic approaches.

TL;DR: Although total reproductive output was not significantly affected at increasing concentrations of polystyrene nanoparticles, there was a decreasing trend in the number of offspring over their life-time, so to understand how the potential future environmental problem of nanoplastic particles may affect biota, long-term or life- time studies resembling environmental concentrations should be performed in order to provide information for predictions of future scenarios in natural aquatic environments.

TL;DR: It is shown that the functional impact of carboxyl-modified polystyrene NPs on these initiators of the intrinsic pathway is size dependent, and enzyme kinetics studies show a critical role for NPs surface area and curvature.