Tommy Cedervall

TL;DR: The results herein show that nanoparticles affect the immune response not only at the cellular level but also on released immune effectors and the nanoparticle effect on myeloperoxidase activity in the neutrophil degranulation environment is the result of an intricate interplay between the enzyme and protein concentrations in the environment and the available surface area on the nanoparticles.

TL;DR: Detailed characterization of the Ca2+-binding and oligomerization properties of each individual EF-hand peptide using CD spectroscopy and analytical ultracentrifugation shows that, in the presence of Ca2+, EF-hands 1, 3, 4, and 5 all form dimers in solution in which the distribution between the monomer, dimer, and higher order oligomers differs.

TL;DR: The results show how nanoparticles released into a natural ecosystem become chemically and physically altered through the dynamic interactions between particles and organisms, either through biological metabolism or through the interactions with biomolecules excreted by organisms into the environment.

TL;DR: The need for more long-term studies if the authors are to understand the effects of nanoparticles in natural systems is emphasized, as the production and usage of nanomaterials are increasing so are the concerns related to the release of the material into nature.

TL;DR: In this paper, the toxic effect of nanoparticles of tungsten carbide cobalt and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules).