This book describes the present state of knowledge regarding the impact of cyanobacteria on health through the use of water. It considers aspects of risk management and details the information needed for protecting drinking water sources and recreational water bodies from the health hazards caused by cyanobacteria and their toxins. It also outlines the state of knowledge regarding the principal considerations in the design of programmes and studies for monitoring water resources and supplies and describes the approaches and procedures used.
The development of this publication was guided by the recommendations of several expert meetings concerning drinking water (Geneva, December 1995; Bad Elster, June
1996) and recreational water (Bad Elster, June 1996; St Helier, May 1997). An expert meeting in Bad Elster, April 1997, critically reviewed the literature concerning the toxicity of cyanotoxins and developed the scope and content of this book. A draft manuscript was reviewed at an editorial meeting in November 1997, and a further draft was
reviewed by the working group responsible for updating the Guidelines for Drinkingwater Quality in March 1998.

/pdf/toxic-cyanobacteria-in-water-a-guide-to-their-public-health-2y64v55hv1.pdf

Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management.

the toxicology of microcystins

https://hal-univ-rennes1.archives-ouvertes.fr/hal-00875835/document

State of knowledge and concerns on cyanobacterial blooms and cyanotoxins.

This study explores the potential use of sulfate radical-based advanced oxidation technologies (SR-AOTs) for the degradation of the naturally occurring hepatotoxin, microcystin-LR (MC-LR). The generation of sulfate radicals was achieved by activation of the oxidants persulfate (PS) and peroxymonosulfate (PMS) through electrophilic transition metal cations (Ag+ and Co2+, respectively), radiation (UV 300  − has similar redox potential to hydroxyl radical (HO ), to the best of our knowledge, SR-AOTs have not been tested for the degradation of cyanotoxins. In this study, PMS was activated very efficiently with Co2+ at neutral pH and increasing catalyst concentration resulted in dramatic increase of the initial rates of degradation that reached a plateau for CCo(II) ≥ 1 mg. Based on the optimum pH conditions for each system, the efficiency order is Co2+/PMS > Fe2+/H2O2 ≫ Ag+/PS, which we believe is associated with the energy of the lower unoccupied molecular orbital of the oxidants. When UV (300  Since, the UV lamps used in the study emit light at a range of wavelengths (300

Degradation of microcystin-LR using sulfate radicals generated through photolysis, thermolysis and e− transfer mechanisms

https://aquaticpath.phhp.ufl.edu/waterbiology/handouts/Microcystins2004.pdf

Microcystin-producing blooms--a serious global public health issue.

Stability of microcystins from cyanobacteria--II. effect of UV light on decomposition and isomerization

Stability of microcystins from cyanobacteria--IV. Effect of chlorination on decomposition.

Toxic cyanobacterial blooms have been frequently observed in Lakes Sagami and Tsukui, Kanagawa Prefecture, Japan, which are used as drinking and recreational water sources. As the first step toward the control and removal of cyanobacterial toxins, the present study evaluated the microcystin level in these lakes. Our established method using HPLC and LC/MS to pursue trace amounts of microcystins was applied to the determination of microcystins within cyanobacteria cells and in water. We could determine precisely the intracellular and extracellular microcystin level in the water environment during 1992-95. Microcystins RR, LR, and YR were detected at 0.02-2.64 micrograms/L in cell-free water and at 0.02-378 micrograms/L in the cells. Although there were many cases in which microcystin concentrations in the cells exceeded the proposed guideline level (1 microgram/L), there was only one example of this happening in cell-free water samples. Because the present monitoring indicated that the amount of microcystins detected in water was much less than that estimated in cells, the release of microcystins from the cells and their stability in lake water were examined in the dark. The resulting toxins persisted at the same concentration level for 14 days and the microcystin concentrations steadily declined, showing that biodegradation using aquatic natural bacterial flora is an effective detoxification process under natural conditions.

Tomohiko Watanuki

Papers

Stability of microcystins from cyanobacteria--II. effect of UV light on decomposition and isomerization

Stability of microcystins from cyanobacteria--IV. Effect of chlorination on decomposition.

Microcystin levels during 1992-95 for Lakes Sagami and Tsukui-Japan.