T
Tomotsuga Ichikawa
Researcher at Harvard University
Publications - 3
Citations - 266
Tomotsuga Ichikawa is an academic researcher from Harvard University. The author has contributed to research in topics: Herpes simplex virus & Amplicon. The author has an hindex of 3, co-authored 3 publications receiving 262 citations.
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Journal ArticleDOI
Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli : rescue of replication-competent virus progeny and packaging of amplicon vectors
Yoshinaga Saeki,Tomotsuga Ichikawa,A Saeki,E A Chiocca,Kurt Tobler,Kurt Tobler,Mathias Ackermann,Xandra O. Breakefield,Cornel Fraefel,Cornel Fraefel +9 more
TL;DR: The capacity of generating infectious and replication-competent HSV-1 progeny following transfection into mammalian cells was restored after insertion of a pac signal into fHSV delta pac, and the resulting amplicon stocks are virtually free of contaminating helper virus.
Journal ArticleDOI
Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors.
Jürgen A. Hampl,Jürgen A. Hampl,Sara M. Camp,Wojciech K. Mydlarz,Monika Hampl,Tomotsuga Ichikawa,E. Antonio Chiocca,David N. Louis,Miguel Sena-Esteves,Xandra O. Breakefield +9 more
TL;DR: A herpes simplex virus-Epstein-Barr virus hybrid amplicon vector containing retrovirus vector components (tribrid vector) that allows conversion of tumor cells into retroviral producer cells is presented and local fourfold amplification of stable transgene expression in tumors is achieved.
Journal ArticleDOI
Gene therapy of brain tumors: problems presented by physiological barriers
TL;DR: The focus of this review will be to describe the obstacles that impede the process of gene therapy and oncolytic viral therapy of brain tumors and to describe how important new discoveries derived from other disciplines are being used to address problems encountered in the gene/ viral Therapy of this disease.