E A Chiocca

TL;DR: Diagnostic criteria for schwannomatosis are needed for both clinicians and researchers, but final diagnostic certainly will await the identification of the schWannom atosis locus itself.

TL;DR: The capacity of generating infectious and replication-competent HSV-1 progeny following transfection into mammalian cells was restored after insertion of a pac signal into fHSV delta pac, and the resulting amplicon stocks are virtually free of contaminating helper virus.

TL;DR: The concept of least resistance, most permission and highest attraction as an essential principle for tumour invasion is introduced and these results support the hypothesis of a self‐organizing adaptive biosystem.

TL;DR: Three mutants of herpes simplex virus type 1 (HSV-1) were used to deliver and express the Escherichia coli lacZ gene in cells of the rat central nervous system, providing a means for the in situ delivery and expression of specific genes in neurons in thecentral nervous system with little adverse effect on animals.

TL;DR: Three vectors derived from retrovirus, herpes simplex virus type 1 (HSV), and adenovirus were compared in cultured rat 9L gliosarcoma cells for gene transfer efficiency and in a 9L rat brain tumor model for histologic pattern and distribution of foreign gene delivery, as well as for associated tumor necrosis and inflammation.