T
Tomoyuki Nakasa
Researcher at Hiroshima University
Publications - 151
Citations - 5502
Tomoyuki Nakasa is an academic researcher from Hiroshima University. The author has contributed to research in topics: Osteoarthritis & Medicine. The author has an hindex of 31, co-authored 124 publications receiving 4740 citations. Previous affiliations of Tomoyuki Nakasa include Alexandria University.
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Journal ArticleDOI
Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue
Tomoyuki Nakasa,Shigeru Miyaki,Atsuko Okubo,Megumi Hashimoto,Keiichiro Nishida,Mitsuo Ochi,Hiroshi Asahara +6 more
TL;DR: This study shows that miR-146 is expressed in RA synovial tissue and that its expression is induced by stimulation with TNFalpha and IL-1beta and further studies are required to elucidate the function of miR -146 in these tissues.
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MicroRNA-140 plays dual roles in both cartilage development and homeostasis
Shigeru Miyaki,Tempei Sato,Atsushi Inoue,Shuhei Otsuki,Yoshiaki Ito,Shigetoshi Yokoyama,Yoshio Kato,Fuko Takemoto,Tomoyuki Nakasa,Satoshi Yamashita,Shuji Takada,Martin Lotz,Hiroe Ueno-Kudo,Hiroshi Asahara +13 more
TL;DR: It is shown that miR-140 regulates cartilage development and homeostasis, and its loss contributes to the development of age-related OA-like changes.
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MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.
Shigeru Miyaki,Tomoyuki Nakasa,Shuhei Otsuki,Shawn P. Grogan,Reiji Higashiyama,Atsushi Inoue,Yoshio Kato,Tempei Sato,Martin Lotz,Hiroshi Asahara +9 more
TL;DR: This study shows that miR-140 has a chondrocyte differentiation-related expression pattern that may contribute to the abnormal gene expression pattern characteristic of OA.
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Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
Yoshihiro Nakamura,Shigeru Miyaki,Hiroyuki Ishitobi,Sho Matsuyama,Tomoyuki Nakasa,Naosuke Kamei,Takayuki Akimoto,Yukihito Higashi,Mitsuo Ochi +8 more
TL;DR: This study suggests that the MSC‐derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR‐494.
Journal ArticleDOI
Expression of MicroRNA-146a in osteoarthritis cartilage.
Keiichiro Yamasaki,Tomoyuki Nakasa,Shigeru Miyaki,Masakazu Ishikawa,Masataka Deie,Nobuo Adachi,Yuji Yasunaga,Hiroshi Asahara,Mitsuo Ochi +8 more
TL;DR: This study shows that miR-146 is intensely expressed in low-grade OA cartilage and that its expression is induced by stimulation of IL-1beta, which might play a role in OAcartilage pathogenesis.