T
Tong Meng
Researcher at Tongji University
Publications - 18
Citations - 1053
Tong Meng is an academic researcher from Tongji University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 5 publications receiving 865 citations.
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Posted ContentDOI
The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes
Hao Zhang,Zijian Kang,Haiyi Gong,Da Xu,Jing Wang,Zifu Li,Xingang Cui,Jianru Xiao,Tong Meng,Wang Zhou,Jianmin Liu,Huji Xu,Huji Xu +12 more
TL;DR: The bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract is provided and may have significant impact for the authors' healthy policy setting regards to prevention of2019-nCoV infection.
Journal ArticleDOI
Digestive system is a potential route of COVID-19: An analysis of single-cell coexpression pattern of key proteins in viral entry process
Hao Zhang,Zijian Kang,Haiyi Gong,Da Xu,Jing Wang,Zhixiu Li,Zifu Li,Xinggang Cui,Jianru Xiao,Jian Zhan,Tong Meng,Wang Zhou,Jianmin Liu,Huji Xu +13 more
TL;DR: This study provides the evidence of the potential route of SARS-CoV-2 in the digestive system along with the respiratory tract based on single-cell transcriptomic analysis and demonstrates a novel method to identify the prime cell types of a virus by the coexpression pattern analysis of single- cell sequencing data.
Posted ContentDOI
The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS
Tong Meng,Cao H,Cao H,Hongwei Zhang,Zijian Kang,Da Xu,Haiyi Gong,Jing Wang,Zhixuan Li,Xingang Cui,Huji Xu,Huji Xu,Haifeng Wei,Xiu-Wu Pan,Ruixin Zhu,Jianru Xiao,Wang Zhou,Cheng L,Jianmin Liu +18 more
TL;DR: The bioinformatics evidence for the increased spike protein cleavage of SARS-CoV-2 is provided and its potential target cells are indicated, including esophageal upper epithelial cells and absorptive enterocytes.
Posted ContentDOI
The transmembrane serine protease inhibitors are potential antiviral drugs for 2019-nCoV targeting the insertion sequence-induced viral infectivity enhancement
Tong Meng,Hao Cao,Hao Cao,Hao Zhang,Zijian Kang,Da Xu,Haiyi Gong,Jing Wang,Zifu Li,Xingang Cui,Huji Xu,Huji Xu,Haifeng Wei,Xiu-Wu Pan,Rongrong Zhu,Jianru Xiao,Wang Zhou,Liming Cheng,Jianmin Liu +18 more
TL;DR: Transmembrane serine protease inhibitors as the antiviral treatment options for 2019-nCoV infection targeting TMPRSS2 are indicated and bioinformatics and structure evidence for the increased viral infectivity of 2019- nCoV is provided.
Posted Content
Identification of a Potential Mechanism of Acute Kidney Injury During the Covid-19 Outbreak: A Study Based on Single-Cell Transcriptome Analysis
Da Xu,Hao Zhang,Haiyi Gong,Jia-xin Chen,Jianqing Ye,Tong Meng,Gan Sishun,Qu Fajun,Chuan-min Chu,Wang Zhou,Xiu-Wu Pan,Linhui Wang,Xingang Cui +12 more