Tong-Yan Liu

TL;DR: In diabetic mice, persistent subcutaneous perfusion of irisin improved the insulin sensitivity, reduced fasting blood glucose, increased GSK3 and Akt phosphorylation, glycogen content and irisin level, and suppressed GS phosphorylated and PEPCK and G6Pase expression in the liver.

TL;DR: It is indicated that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK/mTOR pathway and prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impairedFAO and Autophagy in the liver.

TL;DR: It is proposed that salusin-β may be important in the VSMC migration and neointima of some vascular diseases.

TL;DR: Results indicate that salusin-β promotes VSMC proliferation via cAMP-PKA-EGFR-CREB/ERK pathway and vascular fibrosis via TGF-β1-Smad pathway and contributes to vascular remodeling and hypertension.

TL;DR: Whether activation of melanocortin 3/4 receptors in the PVN modulates sympathetic activity and blood pressure, and whether intracellular signalling involves the cAMP–protein kinase A pathway is addressed.