Toshihiro Seike

TL;DR: It is shown that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity and may be an element in neurodevelopmental disorders.

TL;DR: It is indicated that low concentration of H2 in drinking water can reduce oxidative stress in the brain, and drinking H2-containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative stress and neurodegeneration.

TL;DR: It is suggested that tumor cells and astrocytes stimulate each other and these mutual relationships may be important to understand how lung cancer cells metastasize and develop in the brain.

TL;DR: It is reported that BK attenuated lipopolysaccharide‐induced release of tumor necrosis factor‐alpha (TNF‐α) and interleukin‐1β from microglial cells, thus acting as an anti‐inflammatory mediator in the brain.

TL;DR: In this article, the authors established an animal model for brain metastasis using human lung cancer-derived cells (HARA-B) in nude mice and found that activation of activated microglia was observed around tumor cells depending on the size of metastatic foci and the area of the brain.