H
Hong-Xiang Liu
Researcher at Kanazawa University
Publications - 19
Citations - 1177
Hong-Xiang Liu is an academic researcher from Kanazawa University. The author has contributed to research in topics: Oxytocin & Cyclic ADP-ribose. The author has an hindex of 11, co-authored 16 publications receiving 1072 citations.
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Journal ArticleDOI
CD38 is critical for social behaviour by regulating oxytocin secretion
Duo Jin,Hong-Xiang Liu,Hirokazu Hirai,Takashi Torashima,Taku Nagai,Olga Lopatina,Natalia A. Shnayder,Kiyofumi Yamada,Mami Noda,Toshihiro Seike,Kyota Fujita,Shin Takasawa,Shigeru Yokoyama,Keita Koizumi,Yoshitake Shiraishi,Shigenori Tanaka,Minako Hashii,Toru Yoshihara,Kazuhiro Higashida,Mohammad Saharul Islam,Nobuaki Yamada,Kenshi Hayashi,Naoya Noguchi,Ichiro Kato,Hiroshi Okamoto,Akihiro Matsushima,Alla B. Salmina,Toshio Munesue,Nobuaki Shimizu,Sumiko Mochida,Masahide Asano,Haruhiro Higashida +31 more
TL;DR: It is shown that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity and may be an element in neurodevelopmental disorders.
Journal ArticleDOI
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Toshio Munesue,Shigeru Yokoyama,Kazuhiko Nakamura,Ayyappan Anitha,Kazuo Yamada,Kenshi Hayashi,Tomoya Asaka,Hong-Xiang Liu,Duo Jin,Keita Koizumi,Mohammad Saharul Islam,Jian-Jun Huang,Wen Jie Ma,Uh-Hyun Kim,Sun Jun Kim,Keunwan Park,Dongsup Kim,Mitsuru Kikuchi,Yasuki Ono,Hideo Nakatani,Shiro Suda,Taishi Miyachi,Hirokazu Hirai,Alla B. Salmina,Yu A. Pichugina,Andrei A. Soumarokov,Nori Takei,Norio Mori,Masatsugu Tsujii,Toshiro Sugiyama,Kunimasa Yagi,Masakazu Yamagishi,Tsukasa Sasaki,Hidenori Yamasue,Nobumasa Kato,Ryota Hashimoto,Masako Taniike,Yutaka Hayashi,Jun-ichiro Hamada,Shioto Suzuki,Akishi Ooi,Mami Noda,Yuko Kamiyama,Mizuho A. Kido,Olga Lopatina,Minako Hashii,Sarwat Amina,Fabio Malavasi,Eric J. Huang,Jiasheng Zhang,Nobuaki Shimizu,Takeo Yoshikawa,Akihiro Matsushima,Yoshio Minabe,Haruhiro Higashida +54 more
TL;DR: The immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects is examined and it is found that CD38 was colocalized with OT in secretory neurons.
Journal ArticleDOI
Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
Haruhiro Higashida,Alla B. Salmina,Raissa Ya. Olovyannikova,Minako Hashii,Shigeru Yokoyama,Keita Koizumi,Duo Jin,Hong-Xiang Liu,Olga Lopatina,Sarwat Amina,Mohammad Saharul Islam,Jian-Jun Huang,Mami Noda +12 more
TL;DR: It is possible that pharmacological manipulation of intracellular cadPR levels through ADP-ribosyl cyclase activity or synthetic cADPR analogues may provide new therapeutic opportunities for treatment of neurodevelopmental disorders.
Journal ArticleDOI
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates
Hong-Xiang Liu,Olga Lopatina,Chiharu Higashida,Hiroko Fujimoto,Shirin Akther,Alena Inzhutova,Mingkun Liang,Jing Zhong,Takahiro Tsuji,Toru Yoshihara,Kohei Sumi,Mizuho Ishiyama,Wen Jie Ma,Mitsunori Ozaki,Satoshi Yagitani,Shigeru Yokoyama,Naofumi Mukaida,Takeshi Sakurai,Osamu Hori,Katsuji Yoshioka,Atsushi Hirao,Yukio Kato,Katsuhiko Ishihara,Ichiro Kato,Hiroshi Okamoto,Stanislav M. Cherepanov,Alla B. Salmina,Hirokazu Hirai,Masahide Asano,David Brown,Isamu Nagano,Haruhiro Higashida +31 more
TL;DR: Results show that, in mice, the maternal parent communicates to the paternal parent to encourage pup care, and this new paradigm may be useful in the analysis of the parental brain during paternal care induced by interactive communication.
Journal ArticleDOI
Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice.
Hong-Xiang Liu,Olga Lopatina,Chiharu Higashida,Takahiro Tsuji,Ichiro Kato,Shin Takasawa,Hiroshi Okamoto,Shigeru Yokoyama,Haruhiro Higashida +8 more
TL;DR: Results showed that the reduced severity of behavioral abnormalities in CD38(-/-) pups was due to partial compensation by the high level of plasma OT.