T
Toshinobu Tokumoto
Researcher at Shizuoka University
Publications - 93
Citations - 2013
Toshinobu Tokumoto is an academic researcher from Shizuoka University. The author has contributed to research in topics: Oocyte & Zebrafish. The author has an hindex of 21, co-authored 87 publications receiving 1823 citations. Previous affiliations of Toshinobu Tokumoto include University of Texas at Austin & Graduate University for Advanced Studies.
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Book ChapterDOI
Regulation of oocyte growth and maturation in fish
TL;DR: Of considerable interest is the finding that MIH, unlike most steroid hormones, acts on its receptors at the surface of oocytes, and the mechanism of MIH-induced MPF activation in fish oocytes differs from that in Xenopus and starfish.
Journal ArticleDOI
Cytoplasmic Lipid Droplets Are Sites of Convergence of Proteasomal and Autophagic Degradation of Apolipoprotein B
TL;DR: Observations indicate that both proteasomal and autophagy/lysosomal degradation of ApoB occur around CLDs and that the CLD surface functions as a unique platform for convergence of the two pathways.
Journal ArticleDOI
Induction of Female-to-Male Sex Change in Adult Zebrafish by Aromatase Inhibitor Treatment
Kanae Takatsu,Kaori Miyaoku,Shimi Rani Roy,Yuki Murono,Tomohiro Sago,Hideyuki Itagaki,Masaru Nakamura,Toshinobu Tokumoto +7 more
TL;DR: Results demonstrated that sex plasticity remains in the mature ovaries of this species.
Journal ArticleDOI
Cloning and identification of a membrane progestin receptor in goldfish ovaries and evidence it is an intermediary in oocyte meiotic maturation
TL;DR: Results with the goldfish mPRalpha protein are similar to those obtained previously with spotted seatrout, further supporting the hypothesis that the mPR alpha acts as an intermediary in MIH induction of oocyte maturation in teleosts.
Journal ArticleDOI
Initiation of Cyclin B Degradation by the 26S Proteasome upon Egg Activation
Toshinobu Tokumoto,Masakane Yamashita,Mika Tokumoto,Yoshinao Katsu,Ryo Horiguchi,Hiroko Kajiura,Yoshitaka Nagahama +6 more
TL;DR: The results of this study indicate that Mutant cyclin at K57 was resistant to both digestion by the 26S proteasome and degradation at metaphase/anaphase transition in Xenopus egg extracts, indicating that the destruction of cyclin B is initiated by the ATP-dependent and ubiquitin-independent proteolytic activity of 26S Proteasome through the first cutting in the NH2 terminus ofcyclin.