P
Peter Thomas
Researcher at University of Texas at Austin
Publications - 317
Citations - 20931
Peter Thomas is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Receptor & Membrane progesterone receptor. The author has an hindex of 74, co-authored 315 publications receiving 19538 citations. Previous affiliations of Peter Thomas include Marine Science Institute & Waseda University.
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Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
TL;DR: GPR30, an orphan receptor unrelated to nuclear estrogen receptors, has all the binding and signaling characteristics of a mER, and the identification of a second distinct class of GPCR-like steroid membrane receptors suggests a widespread role for GPCRs in nonclassical steroid hormone actions.
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Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
TL;DR: Cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following seven criteria for its designation as a steroid membrane receptor suggests the fish protein is a membrane progestin receptor mediating a “nonclassical” action of progestins to induce oocyte maturation in fish.
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Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
TL;DR: The identification, cloning, and characteristics of other members of this hitherto unknown family of putative mPRs from several vertebrate species, including human, mouse, pig, Xenopus, zebrafish, and Fugu, with highly conserved nucleotide and deduced amino acid sequences and similar structures to the spotted seatrout mPR are reported.
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Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption.
Peter Thomas,Jing Dong +1 more
TL;DR: Environmental estrogens with relatively high binding affinities for GPR30 also displayed estrogen agonist activities in an in vitro assay of membrane-bound adenylyl cyclase activity, a G PR30-dependent signaling pathway activated by estrogens.
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Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts.
TL;DR: Three distinct estrogen receptor subtypes are described: ERalpha, ERbeta, and a unique type, ERgamma, cloned from a teleost fish, the Atlantic croaker Micropogonias undulatus; the first identification of a third type of classical ER in vertebrate species.