T
Toshinobu Tokumoto
Researcher at Shizuoka University
Publications - 93
Citations - 2013
Toshinobu Tokumoto is an academic researcher from Shizuoka University. The author has contributed to research in topics: Oocyte & Zebrafish. The author has an hindex of 21, co-authored 87 publications receiving 1823 citations. Previous affiliations of Toshinobu Tokumoto include University of Texas at Austin & Graduate University for Advanced Studies.
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Diethylstilbestrol induces fish oocyte maturation.
TL;DR: An endocrine-disrupting chemical, diethylstilbestrol (DES), a nonsteroidal estrogen, triggers oocyte maturation in fish and the structural requirement for the action of DES is discussed based on results obtained with DES analogs.
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Progesterone is a sperm-releasing factor from the sperm-storage tubules in birds.
Tomomi Ito,Norio Yoshizaki,Toshinobu Tokumoto,Hiroko Ono,Takashi Yoshimura,Akira Tsukada,Norio Kansaku,Tomohiro Sasanami +7 more
TL;DR: Evidence is provided for the first time that the progesterone stimulates the release of the resident sperm from the SST and that therelease of the sperm might occur via membrane progestin receptor α-mediating signal transduction.
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Induction and inhibition of oocyte maturation by EDCs in zebrafish.
TL;DR: These results suggest that EDCs act as agonists or antagonists in the induction of oocyte maturation in fish.
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In vivo induction of oocyte maturation and ovulation in zebrafish.
TL;DR: The effect of EDCs on fish oocyte maturation in vivo is demonstrated and a conceptually new approach to distinguish between the genomic and non-genomic actions induced by steroids is explored.
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Interactions of Diethylstilbestrol (DES) and DES Analogs with Membrane Progestin Receptor-α and the Correlation with Their Nongenomic Progestin Activities
TL;DR: The close correspondence between binding of DES and its analogs to the mPR alpha protein and their OM-inducing activities suggests a mechanism of endocrine disruption mediated by binding to mPRalpha resulting in its activation, thereby mimicking the nongenomic action of the progestin 17,20beta-DHP.