T
Toshio Ichihara
Researcher at Institute of Medical Science
Publications - 22
Citations - 522
Toshio Ichihara is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Offspring & Carcinogen. The author has an hindex of 13, co-authored 22 publications receiving 490 citations. Previous affiliations of Toshio Ichihara include Nagoya City University.
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Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Akihiro Hagiwara,Hiroko Yoshino,Toshio Ichihara,Mayumi Kawabe,Seiko Tamano,Hiromitsu Aoki,Takatoshi Koda,Mikio Nakamura,Katsumi Imaida,Nobuyuki Ito,Tomoyuki Shirai +10 more
TL;DR: It is demonstrated that while PhIP clearly exerts promoting effects on DMH-induced colorectal carcinogenesis, these can be reduced by 5.0% PSPC or 5.
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A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague–Dawley rats
Akihiro Hagiwara,Norio Imai,Toshio Ichihara,Toshio Ichihara,Masashi Sano,Seiko Tamano,H Aoki,Kazuo Yasuhara,Takatoshi Koda,Mikio Nakamura,Tomoyuki Shirai +10 more
TL;DR: The No-Observed-Adverse-Effect-Level (NOAEL) was judged to be a dietary level of 0.1% of annatto extract (norbixin), a natural food color, under the present experimental conditions.
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Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N‐ethylnitrosourea induced central nervous system tumors in F344 rats
Tomoyuki Shirai,Mayumi Kawabe,Toshio Ichihara,Osamu Fujiwara,Masao Taki,Soichi Watanabe,Kanako Wake,Yukio Yamanaka,Katsumi Imaida,Makoto Asamoto,Seiko Tamano +10 more
TL;DR: Evaluated whether a 2 year exposure to an electromagnetic field (EMF) equivalent to that generated by cellular phones can accelerate tumor development in the central nervous system (CNS) of rats found it not demonstrated to accelerate or affect ENU initiated brain tumorigenesis.
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Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats.
Kumiko Ogawa,Kyoko Nabae,Jianqing Wang,Kanako Wake,Soichi Watanabe,Mayumi Kawabe,Osamu Fujiwara,Satoru Takahashi,Toshio Ichihara,Seiko Tamano,Tomoyuki Shirai +10 more
TL;DR: No adverse effects of EMF exposure were observed on any reproductive and embryotoxic parameters such as number of live, dead or resorbed embryos, placental weights, sex ratios, weights or external, visceral or skeletal abnormalities of live fetuses.
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Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system
Naomi Hokaiwado,Makoto Asamoto,Kazunari Tsujimura,Takeshi Hirota,Toshio Ichihara,Takatomo Satoh,Tomoyuki Shirai +6 more
TL;DR: It is shown that it is feasible to predict the modifying effects of chemicals on the basis of changes of gene expression patterns after only 2 weeks of exposure, using the novel three‐dimensional microarrays developed by Olympus Optical Co., Ltd.