T
Tracy L. Hartman
Researcher at Southern Research Institute
Publications - 37
Citations - 1019
Tracy L. Hartman is an academic researcher from Southern Research Institute. The author has contributed to research in topics: Nucleoside Reverse Transcriptase Inhibitor & Virus. The author has an hindex of 18, co-authored 36 publications receiving 945 citations. Previous affiliations of Tracy L. Hartman include Rega Institute for Medical Research & Purdue University.
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Journal ArticleDOI
Antiviral Activity of Hop Constituents Against a Series of DNA and RNA Viruses
Victor E. Buckwold,Richard H. Wilson,Aysegul Nalca,Brigitte Beer,Thomas G. Voss,Jim A. Turpin,Robert W. Buckheit,Jiayi Wei,Michelle Wenzel-Mathers,Eve M Walton,Robert J. Smith,Melanie Pallansch,Priscilla A. Ward,Jay Wells,Lara Chuvala,Sandra Sloane,Robin L. Paulman,Julie Russell,Tracy L. Hartman,Roger G. Ptak +19 more
TL;DR: In summary, iso-alpha-acids and xanthohumol were shown to have a low-to-moderate antiviral activity against several viruses and might serve as interesting lead compounds from which more active anti-HCV, anti-Rhino and anti-herpesvirus antiviral agents could be synthesized.
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Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.
Atul Goel,Sharlyn J. Mazur,Rasem J. Fattah,Tracy L. Hartman,Jim A. Turpin,Mingjun Huang,William G. Rice,Ettore Appella,John K. Inman +8 more
TL;DR: A new class of NCp7 inhibitors is reported that possess good antiviral activity with low cellular toxicity and are effective against HIV-1 nucleocapsid protein.
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Carrageenan/MIV-150 (PC-815), a combination microbicide.
José A. Fernández-Romero,Mitchell Thorn,Stuart Turville,Kanani Titchen,Kristin M. Sudol,Jifan Li,Todd Miller,Melissa Robbiani,Robin A. Maguire,Robert W. Buckheit,Tracy L. Hartman,David M. Phillips +11 more
TL;DR: Theoretically, PC-815 is likely to be a more efficacious microbicide than Carraguard in blocking HIV-1 and HIV-2 infections in vitro as compared with Carraguar alone.
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Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.
Bo-Liang Deng,Matthew D. Cullen,Zhigang Zhou,Tracy L. Hartman,Robert W. Buckheit,Christophe Pannecouque,Erik De Clercq,Phillip E. Fanwick,Mark Cushman +8 more
TL;DR: The most potent compound identified was (E)-5-[1-(3,7-dimethyl-2-oxo-2,3-dihydro-benzoxazol-5-yl)-5-methoxycarbonyl-pent-1-enyl]-2- methoxy-3-methylbenzoic acid methyl ester (7), which inhibited the cytopathic effect of HIV-1 in cell culture.
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Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Sakamoto Takeshi,Matthew D. Cullen,Tracy L. Hartman,Karen M. Watson,Robert W. Buckheit,Christophe Pannecouque,Erik De Clercq,Mark Cushman +7 more
TL;DR: The design and synthesis of a new class of ADAMs with N-methoxy imidoyl halide and 1,2,4-oxadiazole systems were attempted and the resulting new ADAM 6 displayed enhanced metabolic stability in rat plasma along with the ability to inhibit HIV-1 reverse transcriptase and the cytopathic effect of HIV- 1RF and HIV-2IIIB at submicromolar concentrations.