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Roger G. Ptak
Researcher at Southern Research Institute
Publications - 76
Citations - 2522
Roger G. Ptak is an academic researcher from Southern Research Institute. The author has contributed to research in topics: Viral replication & Small molecule. The author has an hindex of 26, co-authored 71 publications receiving 2257 citations. Previous affiliations of Roger G. Ptak include Scripps Research Institute.
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Journal ArticleDOI
Cataloguing the HIV type 1 human protein interaction network
Roger G. Ptak,William Fu,Brigitte E Sanders-Beer,Jonathan E. Dickerson,John W. Pinney,David Robertson,Mikhail N. Rozanov,Kenneth S. Katz,Donna Maglott,Kim D. Pruitt,Carl W. Dieffenbach +10 more
TL;DR: This database represents a unique and continuously updated scientific resource for understanding HIV-1 replication and pathogenesis to assist in accelerating the development of effective therapeutic and vaccine interventions.
Journal ArticleDOI
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Roger G. Ptak,Philippe Gallay,Dirk Jochmans,Andrew P. Halestrap,Urs T. Ruegg,Luke A. Pallansch,Michael Bobardt,Marie-Pierre de Béthune,Johan Neyts,Erik De Clercq,Jean-Maurice Dumont,Pietro Scalfaro,Kamel Besseghir,Roland Wenger,Brigitte Rosenwirth +14 more
TL;DR: Debio-025 seems to interfere with the function of CypA during the progression/completion of HIV-1 reverse transcription, and by real-time PCR it is demonstrated that early reverse transcription is reduced in the presence of Debo-025 and that late reverse transcription was almost completely blocked.
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HIV-1, human interaction database: current status and new features
Danso Ako-adjei,William Fu,Craig Wallin,Kenneth S. Katz,Guangfeng Song,Dakshesh Darji,J. Rodney Brister,Roger G. Ptak,Kim D. Pruitt +8 more
TL;DR: A redesigned web interface is introduced to enhance viewing, filtering and downloading of the combined data set of HIV-1 protein–human protein interactions and the inclusion of siRNA interactions.
Journal ArticleDOI
Antiviral Activity of Hop Constituents Against a Series of DNA and RNA Viruses
Victor E. Buckwold,Richard H. Wilson,Aysegul Nalca,Brigitte Beer,Thomas G. Voss,Jim A. Turpin,Robert W. Buckheit,Jiayi Wei,Michelle Wenzel-Mathers,Eve M Walton,Robert J. Smith,Melanie Pallansch,Priscilla A. Ward,Jay Wells,Lara Chuvala,Sandra Sloane,Robin L. Paulman,Julie Russell,Tracy L. Hartman,Roger G. Ptak +19 more
TL;DR: In summary, iso-alpha-acids and xanthohumol were shown to have a low-to-moderate antiviral activity against several viruses and might serve as interesting lead compounds from which more active anti-HCV, anti-Rhino and anti-herpesvirus antiviral agents could be synthesized.
Journal ArticleDOI
Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication
TL;DR: Results indicate that MOV10 has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection.