T
Travis H. Wyman
Researcher at University of Colorado Denver
Publications - 6
Citations - 640
Travis H. Wyman is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Lung injury & NADPH oxidase. The author has an hindex of 6, co-authored 6 publications receiving 618 citations. Previous affiliations of Travis H. Wyman include Gulf Coast Regional Blood Center.
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Journal ArticleDOI
Plasma and lipids from stored platelets cause acute lung injury in an animal model.
Christopher C. Silliman,A. Jason Bjornsen,Travis H. Wyman,Marguerite R. Kelher,Jenny Allard,Sarah Bieber,Norbert F. Voelkel +6 more
TL;DR: It is hypothesize that lipids generated during storage of PLTs cause TRALI in a two‐event animal model and this work states that stored PLTs that contain bioactive lipids contain these lipids.
Journal ArticleDOI
A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
Travis H. Wyman,A. Jason Bjornsen,David J. Elzi,C. Wayne Smith,Kelly M. England,Marguerite R. Kelher,Christopher C. Silliman,Christopher C. Silliman +7 more
TL;DR: Lysophosphatidylcholines (lyso-PCs), generated during blood storage, are etiologic in a two-insult, sepsis-based model of transfusion-related acute lung injury (TRALI).
Journal ArticleDOI
Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
Christopher C. Silliman,David J. Elzi,Daniel R. Ambruso,Rene J. Musters,Christine Hamiel,Ronald J. Harbeck,Andrew J. Paterson,A. Jason Bjornsen,Travis H. Wyman,Marguerite R. Kelher,Kelly M. England,Nathan McLaughlin-Malaxecheberria,Carlton C. Barnett,Junichi Aiboshi,Anirban Bannerjee +14 more
TL;DR: In conclusion, lyso‐PCs affect multiple PMN functions in a Ca2+‐dependent manner that involves the activation of a pertussis toxin‐sensitive G‐protein.
Journal ArticleDOI
Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.
Travis H. Wyman,Charles A. Dinarello,Anirban Banerjee,Fabia Gamboni-Robertson,Andrew A. Hiester,Kelly M. England,Marguerite R. Kelher,Christopher C. Silliman +7 more
TL;DR: It is concluded that IL‐18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity.
Journal ArticleDOI
Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils
David J. Elzi,A. Jason Bjornsen,Todd MacKenzie,Travis H. Wyman,Christopher C. Silliman,Christopher C. Silliman +5 more
TL;DR: The results demonstrate the importance of changes in cytosolic Ca2+ for MAP kinase activation in PMNs and the effects of the Ca2-selective ionophore ionomycin on priming and activation of the PMN oxidase.