T
Trefor Higgins
Researcher at University of Alberta
Publications - 69
Citations - 1407
Trefor Higgins is an academic researcher from University of Alberta. The author has contributed to research in topics: Hemoglobin variants & Hemoglobinopathy. The author has an hindex of 20, co-authored 68 publications receiving 1300 citations.
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Journal ArticleDOI
Laboratory Investigation of Hemoglobinopathies and Thalassemias: Review and Update
TL;DR: The availability of HPLC has streamlined many of these requirements, allowing an efficient stepwise diagnostic strategy for these complex disorders, and several guidelines have been published that outline the required steps for hemoglobinopathy and thalassemia investigation.
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Effects of hemoglobin (Hb) E and HbD traits on measurements of glycated Hb (HbA1c) by 23 methods.
Randie R. Little,Curt L. Rohlfing,Steve Hanson,Shawn Connolly,Trefor Higgins,Cas Weykamp,Mario D'Costa,Veronica Luzzi,William E. Owen,William L. Roberts +9 more
TL;DR: Some current HbA(1c) methods show clinically significant interferences with samples containing HbE or HbD traits, and ion-exchange chromatograms must be carefully examined to identify possible interference from these Hb variants.
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Between-Method Variation in Human Chorionic Gonadotropin Test Results
TL;DR: Differences in assay specificity and in composition of the calibrators are the most likely sources of between-method variation among commercial human chorionic gonadotropin (hCG) assays.
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Current Evidence and Future Perspectives on the Effective Practice of Patient-Centered Laboratory Medicine
Michael J Hallworth,Paul Epner,Christoph Ebert,Corinne R. Fantz,Sherry A Faye,Trefor Higgins,Eric S. Kilpatrick,Wenzhe Li,S. V. Rana,Florent Vanstapel +9 more
TL;DR: This review summarizes existing evidence supporting the impact of laboratory medicine in healthcare and indicates the gaps in understanding, identifies deficiencies in current utilization, suggests potential solutions, and offers a vision of a future in which laboratory medicine is used optimally to support patient care.
Journal ArticleDOI
Measurement of Hba(1C) in patients with chronic renal failure.
Randie R. Little,Curt L. Rohlfing,Alethea L. Tennill,Steven Hanson,Shawn Connolly,Trefor Higgins,Charles E. Wiedmeyer,Cas Weykamp,Richard Krause,William O. Roberts +9 more
TL;DR: Although most methods can measure HbA(1c) accurately in patients with renal failure, healthcare providers must interpret these test results cautiously in these patients due to the propensity for shortened erythrocyte survival in renal failure.