L
Laurence A. Cole
Researcher at University of New Mexico
Publications - 202
Citations - 7422
Laurence A. Cole is an academic researcher from University of New Mexico. The author has contributed to research in topics: Human chorionic gonadotropin & Pregnancy. The author has an hindex of 48, co-authored 201 publications receiving 7108 citations. Previous affiliations of Laurence A. Cole include Yale University.
Papers
More filters
Journal ArticleDOI
Biological functions of hCG and hCG-related molecules
TL;DR: Pituitary hCG seems to mimic luteinizing hormone actions during the menstrual cycle, and hyperglycosylated hCG functions to promote growth of cytotrophoblast cells and invasion by these cells, as occurs in implantation of pregnancy, and growth and invade by choriocarcinoma cells.
Journal ArticleDOI
New discoveries on the biology and detection of human chorionic gonadotropin.
TL;DR: New applications have been demonstrated for total hCG measurements and detection of the 3 hCG variants in pregnancy detection, monitoring pregnancy outcome, determining risk for Down syndrome fetus, predicting preeclampsia, detecting pituitary hCG, detecting and managing gestational trophoblastic diseases, diagnosing quiescent gestationalTrophoblast disease.
Journal ArticleDOI
False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrations
TL;DR: Current protocols for the diagnosis and treatment of choriocarcinoma should be modified to include a compulsory test for hCG in urine.
Journal ArticleDOI
Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma
TL;DR: The evidence of alternative or “hyperbranched” glycoforms on both α- and β-subunits, seen at low levels in normal pregnancy and at increased or even predominant levels in malignant disease, suggests alternative substrate accessibility for Golgi processing enzymes, α1,6fucosyl transferase andN-acetylglucosaminyltransferase IV.
Journal ArticleDOI
Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites
TL;DR: The structure of h CG and related molecules is reviewed, and recognition of hCG-related molecules by different types of immunoassay is examined.