T
Trey Coleman
Researcher at Washington University in St. Louis
Publications - 41
Citations - 4528
Trey Coleman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 31, co-authored 41 publications receiving 4204 citations.
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Journal ArticleDOI
New hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
Manu V. Chakravarthy,Zhijun Pan,Yimin Zhu,Karen Tordjman,Jochen G. Schneider,Trey Coleman,John Turk,Clay F. Semenkovich +7 more
TL;DR: It is suggested that products of the FAS reaction regulate glucose, lipid, and cholesterol metabolism by serving as endogenous activators of distinct physiological pools of PPARalpha in adult liver.
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Autophagy Links Inflammasomes to Atherosclerotic Progression
Babak Razani,Chu Feng,Trey Coleman,Roy Emanuel,Haitao Wen,Seungmin Hwang,Jenny P.-Y. Ting,Herbert W. Virgin,Michael B. Kastan,Clay F. Semenkovich +9 more
TL;DR: Results show that autophagy becomes dysfunctional in Atherosclerosis and its deficiency promotes atherosclerosis in part through inflammasome hyperactivation.
Journal ArticleDOI
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.
Bing Li,Lorraine A. Nolte,Jeong-Sun Ju,Dong Ho Han,Trey Coleman,John O. Holloszy,Clay F. Semenkovich +6 more
TL;DR: In this article, the mitochondrial uncoupling protein (Ucp) was found to be a suitable treatment for obesity and type 2 diabetes in transgenic mice expressing UCP in skeletal muscle.
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A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes
Brian N. Finck,Carlos Bernal-Mizrachi,Dong Ho Han,Trey Coleman,Nandakumar Sambandam,Lori L. LaRiviere,John O. Holloszy,Clay F. Semenkovich,Daniel P. Kelly +8 more
TL;DR: PPARalpha-driven alterations in muscle fatty acid oxidation and energetics are identified as a potential link between obesity and the development of glucose intolerance and insulin resistance.
Journal ArticleDOI
Diet-induced Diabetes Activates an Osteogenic Gene Regulatory Program in the Aortas of Low Density Lipoprotein Receptor-deficient Mice
TL;DR: High fat diets associated with hyperinsulinemic diabetes activate an aortic osteoblast transcriptional regulatory program that is independent of intimal atheroma formation, suggesting that vascular calcification, thought to be limited to the media, is an active process that can originate from an osteoprogenitor cell population in the adventitia.